Vaccines for the Prevention of Melioidosis and Glanders

被引：7

作者：

Johnson M.M. ^{[1
]}

Ainslie K.M. ^{[1
]}

机构：

[1] Division of Pharmacoengineering and Molecular Pharmaceutics, Eshelman School of Pharmacy, The University of North Carolina at Chapel Hill, 4211 Marsico Hall, 125 Mason Farm Road, Chapel Hill, 27599, NC

来源：

Current Tropical Medicine Reports | 2017年 / 4卷 / 3期

关键词：

Burkholderia mallei; Burkholderia pseudomallei; Glanders; Melioidosis; Vaccines;

D O I：

10.1007/s40475-017-0121-7

中图分类号：

学科分类号：

摘要：

Purpose of Review: Burkholderia pseudomallei’s and Burkholderia mallei’s high rate of infectivity, limited treatment options, and potential use as biological warfare agents underscore the need for development of effective vaccines against these bacteria. Research efforts focused on vaccines against these bacteria are in preclinical stages, with no approved formulations currently on the market. Recent Findings: Several live attenuated and subunit vaccine formulations have been evaluated in animal studies, with no reports of significant long-term survival after lethal challenge. Summary: This review encompasses the most current vaccine strategies to prevent B. pseudomallei and B. mallei infections while providing insight for successful vaccines moving forward. © 2017, Springer International Publishing AG.

引用

页码：136 / 145

页数：9

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