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Chinese Acad Med Sci & Peking Union Med Coll, CAMS Key Lab Antiviral Drug Res, Beijing Key Lab Antimicrobial Agents, NHC Key Lab Biotechnol Antibiot,Inst Med Biotechn, Beijing 100050, Peoples R China Beijing Inst Technol, Sch Life Sci, Key Lab Mol Med & Biotherapy, Key Lab Med Mol Sci & Pharmaceut Engn, Beijing 100081, Peoples R China