A novel quality assurance system for eye plaque brachytherapy

Eye Plaque brachytherapy pre-treatment quality assurance (QA) conducted clinically involves an activity verification of individual seeds via well chamber and does not include a physical measurement of dose-rate of the final assembly. A novel spectroscopic, dose-rate detection system, was evaluated for pre-treatment QA of eye plaque brachytherapy. The system includes a water phantom with sterility management. The system was calibrated using a known-activity I-125 seed, measured at 1 cm in water along the radial axis, compared to TG-43 U1 calculations and verified over a number of distances. A depth dose curve was acquired for a clinical, mixed activity eye plaque and two ‘error’ plaques. The probe was stepped from a water equivalent source to a detector distance (SDD) of 2.5 to 12 mm along the plaque central axis. The latter measurements aimed to characterise the sensitivity of the system. The calculated and measured single-seed dose-rates agreed to within 0.5 cGy/h from a SDD of 3 mm and above. The clinical plaque showed agreement between measured and treatment planning system (TPS) calculated dose-rates within 2%. Sensitivity testing resulted in a maximum deviation from TPS data of 18%, therefore was able to detect the presence of packing errors. The dose-rate detection system was successfully evaluated for verification of I-125 based eye plaques without compromising sterility, allowing for quick pre-treatment, dose-rate verification of patient-ready plaques. Its agreement with TPS data for the unmodified plaque and its deviation when introducing errors confirms the approach suggested is a viable QA tool.