Biocompatible Polyhydroxyethylaspartamide-based Micelles with Gadolinium for MRI Contrast Agents

被引：0
|
作者：
Sang Young Jeong
Hyo Jeong Kim
Byung-Kook Kwak
Ha-Young Lee
Hasoo Seong
Byung Cheol Shin
Soon Hong Yuk
Sung-Joo Hwang
Sun Hang Cho
机构：
[1] Chungnam National University,College of Pharmacy
[2] KRICT,Center for Drug Discovery Technology
[3] Chung-Ang University,College of Medicine
来源：
Nanoscale Research Letters | / 5卷
关键词：
MRI contrast agent; PHEA derivatives; Micelles; Nanoparticles; Gd contrast agent;
D O I：
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中图分类号：
学科分类号：
摘要：
Biocompatible poly-[N-(2-hydroxyethyl)-d,l-aspartamide]-methoxypoly(ethyleneglycol)-hexadecylamine (PHEA-mPEG-C16) conjugated with 1,4,7,10-tetraazacyclododecan-1,4,7,10-tetraacetic acid-gadolinium (DOTA-Gd) via ethylenediamine (ED) was synthesized as a magnetic resonance imaging (MRI) contrast agent. Amphiphilic PHEA-mPEG-C16-ED-DOTA-Gd forms micelle in aqueous solution. All the synthesized materials were characterized by proton nuclear magnetic resonance (1H NMR). Micelle size and shape were examined by dynamic light scattering (DLS) and atomic force microscopy (AFM). Micelles with PHEA-mPEG-C16-ED-DOTA-Gd showed higher relaxivities than the commercially available gadolinium contrast agent. Moreover, the signal intensity of a rabbit liver was effectively increased after intravenous injection of PHEA-mPEG-C16-ED-DOTA-Gd.
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