Different patterns of functional and structural alterations of hippocampal sub-regions in subcortical vascular mild cognitive impairment with and without depression symptoms

被引:0
|
作者
Jinping Xu
Jianjun Wang
Hanqing Lyu
Xuejia Pu
Ziyun Xu
Yuanming Hu
Zhouke Guo
Haibo Yu
Qingmao Hu
机构
[1] Institute of Biomedical and Health Engineering,Department of Neurology and Psychiatry, Shenzhen Traditional Chinese Medicine Hospital / the Fourth Clinical Medical College
[2] Shenzhen Institutes of Advanced Technology,Department of Radiology, Shenzhen Traditional Chinese Medicine Hospital / the Fourth Clinical Medical College
[3] Chinese Academy of Sciences,Department of Acupuncture and Moxibustion
[4] University of Chinese Academy of Sciences,CAS Key Laboratory of Human
[5] Guangzhou University of Chinese Medicine,Machine Intelligence
[6] Guangzhou University of Chinese Medicine,Synergy Systems, Shenzhen Institutes of Advanced Technology
[7] Shenzhen Traditional Chinese Medicine Hospital,undefined
[8] Chinese Academy of Sciences,undefined
来源
Brain Imaging and Behavior | 2021年 / 15卷
关键词
Subcortical vascular mild cognitive impairment; Depression symptoms; Hippocampal sub-regions; Structural associations; And resting-state functional connectivity;
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学科分类号
摘要
In addition to cognitive impairments, depression symptoms were reported in subcortical vascular mild cognitive impairment. Although hippocampal alterations were associated with cognitive decline in subcortical vascular mild cognitive impairment, the neural mechanism underlying depression symptoms remains unclear. Thus, a cohort of 18 patients with depression symptoms, 17 patients without depression symptoms, and 23 normal controls was used. Functionally, significantly altered resting-state functional connectivity between hippocampal emotional sub-region and right posterior cingulate cortex, between hippocampal cognitive sub-region and right inferior parietal gyrus and between hippocampal perceptual sub-region and left inferior temporal gyrus were identified among three groups. Structurally, significantly altered structural associations between hippocampal emotional sub-region and 6 frontal regions/right pole part of superior temporal gyrus/right inferior occipital gyrus, between hippocampal cognitive sub-region and right orbital part of inferior frontal gyrus /right anterior cingulate cortex, and between hippocampal perceptual and right orbital part of inferior frontal gyrus / left inferior temporal gyrus / left thalamus were identified among the three groups. Further analyses also showed correlations between functional connectivity and depression symptoms and/or cognitive impairments of patients. Together, these results showed different patterns of functional and structural alterations of the hippocampal sub-regions in the subcortical vascular mild cognitive impairment with and without depression, which might be specially associated with the depression symptoms and cognitive impairments in these patients.
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页码:1211 / 1221
页数:10
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