Organoid: a powerful tool to study lung regeneration and disease

被引：0
作者：
Tiantian Lu
Yiyuan Cao
Peng Zhao
Shengxi Shen
Ying Xi
机构：
[1] ShanghaiTech University,School of Life Science and Technology
来源：
Cell Regeneration | / 10卷
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摘要：
Organoids are three-dimensional self-organizing structures formed by adult tissue stem cells or pluripotent stem cells. They recapitulate cell-cell, cell-niche interactions in tissue development, homeostasis, regeneration and disease, and provide an in vitro model for drug screening. This review summarizes the recent advances of organoid cultures derived from adult lung stem cells and human pluripotent stem cells, especially focusing on the organoids of the distal airway stem/progenitor cells. We also discuss the applications of organoids in studying lung regeneration and pulmonary diseases, including pulmonary fibrosis, airway diseases and Coronavirus disease 2019 (COVID-19).
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