The Influence of the Compression Force on Zidovudine Release from Matrix Tablets

被引：0
作者：
Jucimary V. Santos
Luís A. E. Batista de Carvalho
Maria Eugénia Tavares Pina
机构：
[1] University of Coimbra,Centro de Estudos Farmacêuticos (CEF), Faculty of Pharmacy
[2] University of Coimbra,Molecular Physical–Chemistry R&D Unit, Chemistry Department, Faculty of Sciences and Technology
来源：
AAPS PharmSciTech | 2010年 / 11卷
关键词：
compression force; Eudragit® RL PO; Eudragit® RS PO; HPMC; sustained release; zidovudine;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
The aim of the present work is the study of different zidovudine (AZT) formulations containing polymers (both cellulosic and acrylic), in order to evaluate the influence of the compression force on the antiviral release from the matrix tablets. The results evidenced that the formulations compressed at 500 and 1,000 MPa exhibit a higher hardness than those prepared at 100 MPa. The effect of the compression force on the drug release was analyzed and a statistically significant difference was observed (P < 0.05). Using lower compression forces leads to slightly better release profiles, i.e., profiles close to an ideal Higuchi kinetics for a total release of drug in a 12-h period, allowing to conclude that a compression force higher than 100 MPa is unnecessary.
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页码：1442 / 1448
页数：6
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