Recent Applications of Kirkwood–Buff Theory to Biological Systems

被引：0
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作者：
Veronica Pierce
Myungshim Kang
Mahalaxmi Aburi
Samantha Weerasinghe
Paul E. Smith
机构：
[1] Kansas State University,Department of Chemistry, 111 Willard Hall
[2] Columbia University,Center for Molecular Recognition, Building for Physicians & Surgeons 11
[3] University of Colombo,401
来源：
Cell Biochemistry and Biophysics | 2008年 / 50卷
关键词：
Preferential binding; Preferential interactions; Kirkwood–Buff theory; Protein denaturation; Cosolvents; Osmolytes; Computer simulation;
D O I：
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学科分类号：
摘要：
The effect of cosolvents on biomolecular equilibria has traditionally been rationalized using simple binding models. More recently, a renewed interest in the use of Kirkwood–Buff (KB) theory to analyze solution mixtures has provided new information on the effects of osmolytes and denaturants and their interactions with biomolecules. Here we review the status of KB theory as applied to biological systems. In particular, the existing models of denaturation are analyzed in terms of KB theory, and the use of KB theory to interpret computer simulation data for these systems is discussed.
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页码：1 / 22
页数：21
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