Synthesis of Novel Thiol-Reactive Amphiphilic Lipids Based on Cholesterol for Protein-Liposome CouplingSynthese neuartiger thiol-reaktiver amphiphiler Lipide auf Cholesterolbasis für die Kopplung von Proteinen an Liposomen

被引：0

作者：

Jörg T. Kley

Thomas Fichert

Ulrich Massing

机构：

[1] Tumor Biology Center,

[2] Department of Medical Oncology,undefined

[3] Division of Medical Research,undefined

[4] D-79106 Freiburg,undefined

[5] FRG,undefined

来源：

Monatshefte für Chemie / Chemical Monthly | 1998年 / 129卷 / 3期

关键词：

Keywords. Maleimides; Polyethylene glycols; Cholesterol derivatives; Synthesis of; Liposomes.;

D O I：

10.1007/PL00000090

中图分类号：

学科分类号：

摘要：

The synthesis of a series of coupling lipids designed for covalently linking proteins to liposomes is described. The new compounds have in common a cholesterylsuccinyl unit as a lipid anchor and a thiol-reactive maleimidobenzoyl unit which are linked by alkyl or (poly)ethylene glycol spacers that differ in length and polarity.

引用

页码：319 / 327

页数：8