Synthesis of pyrido[3′,2′:4,5]thieno[2,3-c]cinnolines - A new heterocyclic system

被引：0

作者：

Artemov V.A. ^{[1
]}

Ivanov V.L. ^{[1
]}

Koshkarov A.V. ^{[1
]}

Shestopalov A.M. ^{[1
]}

Litvinov V.P. ^{[1
]}

机构：

[1] N. D. Zelinskii Institute of Organic Chemistry, Russian Academy of Sciences

来源：

Chemistry of Heterocyclic Compounds | 1998年 / 34卷 / 1期

关键词：

Bromide; Organic Chemistry; Pyridine; Alkylation; Thiophene;

D O I：

10.1007/BF02290619

中图分类号：

学科分类号：

摘要：

Pyrido[3′,2′:4,5]thieno[2,3-c]cinnolines, new heterocyclic compounds, were obtained in three steps: 1) alkylation of 3-cyanopyridine-2(1H)-thiones by o-nitrobenzyl bromide to give 2-(o-nitrobenzyl)thio-3-cyanopyridines, 2) closure of the thiophene ring in these intermediates to give 3-amino-2-(o-nitrophenyl)thieno[2,3-b]pyridines, and 3) closure of the pyridazine ring by condensation of the amino and nitro groups in triethyl phosphite, leading to the final heterocyclic system. ©1998 Plenum Publishing Corporation.

引用

页码：96 / 101

页数：5

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