Fibroadenoma in vulval ectopic breast tissue in a patient with PTEN Hamartoma Tumour Syndrome

被引：0

作者：

Hannah Dawson

Alannah Smrke

Peter M. Ellery

Nafisa Wilkinson

Adam N. Rosenthal

Terri P. McVeigh

机构：

[1] The Royal Marsden Hospital NHS Foundation Trust,Department of Cellular Pathology

[2] University College London Hospitals NHS Foundation Trust,Department of Women’s Cancer, Institute for Women’s Health

[3] University College London,undefined

来源：

Familial Cancer | 2022年 / 21卷

关键词：

Cowden syndrome; Vulval fibroadenoma; Ectopic breast tissue; hamartoma tumour syndrome;

D O I：

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学科分类号：

摘要：

PTEN is a tumour suppressor gene involved in regulating cell division. Pathogenic germline variants in PTEN predispose to benign and malignant growths of numerous organs, including of the breast. In the following report, we describe the first documented case of a fibroadenoma developing in ectopic breast tissue of the vulva in a patient with a germline pathogenic variant in PTEN. This highlights the risk of hyperplasia developing in any breast tissue, including rare ectopic sites, particularly in patients with underlying germline variants in cancer susceptibility genes.

引用

页码：363 / 368

页数：5