MHC class I chain-related protein A and B (MICA and MICB) are predominantly expressed intracellularly in tumour and normal tissue

Aguera-Gonzalez S(2009)Brief residence at the plasma membrane of the MHC class I-related chain B is due to clathrin-mediated cholesterol-dependent endocytosis and shedding J Immunol 182 4800-4808

Boutet P(2011)Palmitoylation of MICA, a ligand for NKG2D, mediates its recruitment to membrane microdomains and promotes its shedding Eur J Immunol 41 3667-3676

Reyburn HT(2013)Broad MICA/B expression in the small bowel mucosa: a link between cellular stress and celiac disease PLoS One 8 e73658-489

Vales-Gomez M(2010)Natural killer cell cytotoxicity is suppressed by exposure to the human NKG2D ligand MICA*008 that is shed by tumor cells in exosomes Cancer Res 70 481-1626

Aguera-Gonzalez S(2011)Novel role for STAT3 in transcriptional regulation of NK immune cell targeting receptor MICA on cancer cells Cancer Res 71 1615-4086

Gross CC(2011)Expression, signaling proficiency, and stimulatory function of the NKG2D lymphocyte receptor in human cancer cells Proc Natl Acad Sci USA 108 4081-53

Fernandez-Messina L(2009)Cutting edge: the metalloproteinase ADAM17/TNF-alpha-converting enzyme regulates proteolytic shedding of the MHC class I-related chain B protein J Immunol 182 49-1566

Ashiru O(2013)Shedding of endogenous MHC class I-related chain molecules A and B from different human tumor entities: heterogeneous involvement of the ‘a disintegrin and metalloproteases’ 10 and 17 Int J Cancer 133 1557-213

Esteso G(2005)Exosomes and the MICA-NKG2D system in cancer Blood Cells Mol Dis 34 206-1717

Hang HC(2005)Altered NKG2D function in NK cells induced by chronic exposure to NKG2D ligand-expressing tumor cells Blood 106 1711-93

Aguera-Gonzalez S(2009)Brief residence at the plasma membrane of the MHC class I-related chain B is due to clathrin-mediated cholesterol-dependent endocytosis and shedding J Immunol 182 4800-4808

Boutet P(2011)Palmitoylation of MICA, a ligand for NKG2D, mediates its recruitment to membrane microdomains and promotes its shedding Eur J Immunol 41 3667-3676

Reyburn HT(2013)Broad MICA/B expression in the small bowel mucosa: a link between cellular stress and celiac disease PLoS One 8 e73658-489

Vales-Gomez M(2010)Natural killer cell cytotoxicity is suppressed by exposure to the human NKG2D ligand MICA*008 that is shed by tumor cells in exosomes Cancer Res 70 481-1626

Aguera-Gonzalez S(2011)Novel role for STAT3 in transcriptional regulation of NK immune cell targeting receptor MICA on cancer cells Cancer Res 71 1615-4086

Gross CC(2011)Expression, signaling proficiency, and stimulatory function of the NKG2D lymphocyte receptor in human cancer cells Proc Natl Acad Sci USA 108 4081-53

Fernandez-Messina L(2009)Cutting edge: the metalloproteinase ADAM17/TNF-alpha-converting enzyme regulates proteolytic shedding of the MHC class I-related chain B protein J Immunol 182 49-1566

Ashiru O(2013)Shedding of endogenous MHC class I-related chain molecules A and B from different human tumor entities: heterogeneous involvement of the ‘a disintegrin and metalloproteases’ 10 and 17 Int J Cancer 133 1557-213

Esteso G(2005)Exosomes and the MICA-NKG2D system in cancer Blood Cells Mol Dis 34 206-1717

Hang HC(2005)Altered NKG2D function in NK cells induced by chronic exposure to NKG2D ligand-expressing tumor cells Blood 106 1711-93