Pathophysiology of vascular dementia

被引：47
作者：
Iemolo F. [1 ,2 ,3 ,4 ]
Duro G. [4 ]
Rizzo C. [5 ,6 ]
Castiglia L. [5 ,6 ]
Hachinski V. [1 ]
Caruso C. [5 ,6 ]
机构：
[1] Department of Clinical Neurological Sciences, University of Western Ontario, Ontario
[2] Robarts Research Institute Stroke Prevention, Atherosclerosis Research Centre, London, England
[3] U.O. di Neurologia, Ospedale di Vittoria, ASL7-Ragusa and Clinica Neurologica Università di Catania, Catania
[4] Istituto di Biomedicina ed Immunologia Molecolare(IBIM), Consiglio Nazionale delle Ricerche (CNR), Palermo
[5] U.O. di Immunoematologia e Medicina Trasfusionale, AOUP Paolo Giaccone, Palermo
[6] Dipartimento di Biopatologia e Metodologie Biomediche, Università di Palermo, Palermo
来源：
Immunity & Ageing | / 6卷 / 1期
关键词：
Dementia; Alzheimer Disease; Vascular Dementia; Cerebral Amyloid Angiopathy; Small Vessel Disease;
D O I：
10.1186/1742-4933-6-13
中图分类号：
学科分类号：
摘要：
The concept of Vascular Dementia (VaD) has been recognized for over a century, but its definition and diagnostic criteria remain unclear.Conventional definitions identify the patients too late, miss subjects with cognitive impairment short of dementia, and emphasize consequences rather than causes, the true bases for treatment and prevention. We should throw out current diagnostic categories and describe cognitive impairment clinically and according to commonly agreed instruments that document the demographic data in a standardized manner and undertake a systematic effort to identify the underlying aetiology in each case.Increased effort should be targeted towards the concept of and criteria for Vascular Cognitive Impairment and Post-Stroke Dementia as well as for genetic factors involved, especially as these categories hold promise for early prevention and treatment. © 2009 Iemolo et al; licensee BioMed Central Ltd.
引用
收藏
相关论文
共 90 条
  • [1] Leblanc G.G., Meschia J.F., Stuss D.T., Hachinski V., Genetics of Vascular Cognitive Impairment The Opportunity and the Challenges, Stroke, 37, pp. 248-255, (2006)
  • [2] Rockwood K., Wentzel C., Hachinski V., Hogan D.B., MacKnight C., McDowell I., Prevalence and outcomes of vascular cognitive impairment, Neurology, 54, pp. 447-451, (2000)
  • [3] Petersen R.C., Aging, mild cognitive impairment, and Alzheimer's disease, Neurol Clin, 18, pp. 789-806, (2000)
  • [4] Candore G., Balistreri C.R., Grimaldi M.P., Vasto S., Listi F., Chiappelli M., Licastro F., Lio D., Caruso C., Age-related inflammatory diseases: role of genetics and gender in the pathophysiology of Alzheimer's disease, Ann N Y Acad Sci, 1089, pp. 472-486, (2006)
  • [5] Roman G.C., A historical review of the concept of vascular dementia: lessons from the past for the future, Alzheimer Dis Assoc Disord, 13, (1999)
  • [6] Caruso C., Franceschi C., Licastro F., Genetics of neurodegenerative disorders, N Engl J Med, 349, pp. 193-194, (2003)
  • [7] Roman G.C., Historical aspects: from Alzheimer to Binswanger, pp. 83-85, (1992)
  • [8] Beach T.G., The history of Alzheimer's disease: three debates, Hist Med Allied Sci, 42, pp. 327-349, (1987)
  • [9] Berrios G.E., Alzheimer's disease: a conceptual history, Int J Geriat Psych, 5, pp. 355-365, (1990)
  • [10] Berrios G.E., Freeman H.L., Alzheimer and the dementias. London, Royal Society of Medicine Ser, (1991)
123456789