Preliminary Study of the Impact of Single-Nucleotide Polymorphisms of IL-1α, IL-1β and TNF-α Genes on the Occurrence, Severity and Treatment Effectiveness of the Major Depressive Disorder

被引：0
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作者：
Katarzyna Bialek
Piotr Czarny
Cezary Watala
Ewelina Synowiec
Paulina Wigner
Michal Bijak
Monika Talarowska
Piotr Galecki
Janusz Szemraj
Tomasz Sliwinski
机构：
[1] University of Lodz,Laboratory of Medical Genetics, Faculty of Biology and Environmental Protection
[2] Medical University of Lodz,Department of Medical Biochemistry
[3] Medical University of Lodz,Department of Haemostatic Disorders
[4] University of Lodz,Biohazard Prevention Centre, Faculty of Biology and Environmental Protection
[5] Institute of Psychology,Department of Personality and Individual Differences
[6] University of Lodz,Department of Adult Psychiatry
[7] Medical University of Lodz,undefined
来源：
Cellular and Molecular Neurobiology | 2020年 / 40卷
关键词：
Major depressive disorder; Inflammation; Single nucleotide polymorphism; Cytokine;
D O I：
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学科分类号：
摘要：
The purpose of the preliminary study was to determine whether the occurrence of certain SNPs of genes encoding IL-1α, IL-1β, and TNF-α is associated with the development of depression. Five polymorphisms were selected: i.e. c.-1560G > C—IL-1β (rs1143623), c. -118 C > T—IL-1β (rs1143627), c.340G > T—IL-1α (rs17561), c.-1211T > C—TNF-α (rs1799964) and c.-488G > A—TNF-α (rs1800629). These were analyzed using TaqMan probes. The genotypes of the analyzed polymorphisms were found to be associated with disease severity and may affect the effectiveness of antidepressant therapy. In addition, the gene–gene analysis confirmed that combined genotypes of investigated SNPs may modulate the risk of depression.
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页码：1049 / 1056
页数：7
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