Brain Insulin Dysregulation: Implication for Neurological and Neuropsychiatric Disorders

被引：0
作者：
Rasoul Ghasemi
Leila Dargahi
Ali Haeri
Maryam Moosavi
Zahurin Mohamed
Abolhassan Ahmadiani
机构：
[1] Shiraz University of Medical Sciences,Neuroscience Research Center and Department of Physiology
[2] Shahid Beheshti University of Medical Sciences,Neuroscience Research Center
[3] Shahid Beheshti University of Medical Sciences,Department of Pharmacology, Faculty of Medicine
[4] University of Malaya,Department of Pharmacology, Faculty of Medicine
来源：
Molecular Neurobiology | 2013年 / 47卷
关键词：
Insulin; Diabetes mellitus; Alzheimer’s disease; Parkinson’s disease; Huntington’s disease; Depression; Schizophrenia;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Arduous efforts have been made in the last three decades to elucidate the role of insulin in the brain. A growing number of evidences show that insulin is involved in several physiological function of the brain such as food intake and weight control, reproduction, learning and memory, neuromodulation and neuroprotection. In addition, it is now clear that insulin and insulin disturbances particularly diabetes mellitus may contribute or in some cases play the main role in development and progression of neurodegenerative and neuropsychiatric disorders. Focusing on the molecular mechanisms, this review summarizes the recent findings on the involvement of insulin dysfunction in neurological disorders like Alzheimer’s disease, Parkinson’s disease and Huntington’s disease and also mental disorders like depression and psychosis sharing features of neuroinflammation and neurodegeneration.
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页码：1045 / 1065
页数：20
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