Cisplatin-resistant A549 non-small cell lung cancer cells can be identified by increased mitochondrial mass and are sensitive to pemetrexed treatment

[1] Treat J(2012)Comparison of pemetrexed plus cisplatin with other first-line doublets in advanced non-small cell lung cancer (NSCLC): a combined analysis of three phase 3 trials Lung Cancer 76 222-227

[2] Scagliotti GV(2011)Identification of a de novo thymidylate biosynthesis pathway in mammalian mitochondria Proc Natl Acad Sci USA 108 15163-15168

[3] Peng G(2012)Glycine decarboxylase activity drives non-small cell lung cancer tumor-initiating cells and tumorigenesis Cell 148 259-272

[4] Monberg MJ(2015)Targeting mitochondria metabolism for cancer therapy Nat Chem Biol 11 9-15

[5] Obasaju CK(2015)High mitochondrial mass identifies a sub-population of stem-like cancer cells that are chemo-resistant Oncotarget 6 30472-30486

[6] Socinski MA(2015)Antibiotics that target mitochondria effectively eradicate cancer stem cells, across multiple tumor types: treating cancer like an infectious disease Oncotarget 6 4569-4584

[7] Anderson DD(2014)Oncogene ablation-resistant pancreatic cancer cells depend on mitochondrial function Nature 514 628-632

[8] Quintero CM(2016)Migration and invasion of drug-resistant lung adenocarcinoma cells are dependent on mitochondrial activity Exp Mol Med 48 e277-546

[9] Stover PJ(2011)Kinetics of the cell biological changes occurring in the progression of DNA damage-induced senescence Mol Cells 31 539-893

[10] Zhang WC(2015)Polyploidy Formation in doxorubicin-treated cancer cells can favor escape From senescence Neoplasia 17 882-574

[1] Treat J(2012)Comparison of pemetrexed plus cisplatin with other first-line doublets in advanced non-small cell lung cancer (NSCLC): a combined analysis of three phase 3 trials Lung Cancer 76 222-227

[2] Scagliotti GV(2011)Identification of a de novo thymidylate biosynthesis pathway in mammalian mitochondria Proc Natl Acad Sci USA 108 15163-15168

[3] Peng G(2012)Glycine decarboxylase activity drives non-small cell lung cancer tumor-initiating cells and tumorigenesis Cell 148 259-272

[4] Monberg MJ(2015)Targeting mitochondria metabolism for cancer therapy Nat Chem Biol 11 9-15

[5] Obasaju CK(2015)High mitochondrial mass identifies a sub-population of stem-like cancer cells that are chemo-resistant Oncotarget 6 30472-30486

[6] Socinski MA(2015)Antibiotics that target mitochondria effectively eradicate cancer stem cells, across multiple tumor types: treating cancer like an infectious disease Oncotarget 6 4569-4584

[7] Anderson DD(2014)Oncogene ablation-resistant pancreatic cancer cells depend on mitochondrial function Nature 514 628-632

[8] Quintero CM(2016)Migration and invasion of drug-resistant lung adenocarcinoma cells are dependent on mitochondrial activity Exp Mol Med 48 e277-546

[9] Stover PJ(2011)Kinetics of the cell biological changes occurring in the progression of DNA damage-induced senescence Mol Cells 31 539-893

[10] Zhang WC(2015)Polyploidy Formation in doxorubicin-treated cancer cells can favor escape From senescence Neoplasia 17 882-574