Vaccination Against Rheumatic Heart Disease: A Review of Current Research Strategies and Challenges

被引：0
作者：
Manisha Pandey
Michael R. Batzloff
Michael F. Good
机构：
[1] Griffith University,Institute for Glycomics
[2] Griffith University,Institute for Glycomics
[3] Griffith University,Institute for Glycomics
来源：
Current Infectious Disease Reports | 2012年 / 14卷
关键词：
Acute rheumatic fever; Rheumatic heart disease; Vaccines; Pyoderma; Pharyngitis; Tropical and temperate regions; Animal models;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Acute rheumatic fever (ARF) and rheumatic heart disease (RHD) are major health problems in many developing countries and Indigenous populations of developed countries. ARF and RHD are sequelae resulting from an infection of Streptococcus pyogenes. Despite advances in health care practices and technology, these diseases still pose major challenges in the communities where Streptococcus pyogenes is often endemic. Here we review and discuss the dynamic epidemiology of streptococcal infection and its associated diseases (ARF and RHD), with a focus on disease burden in temperate versus tropical regions, the tissue tropism of the organism and the efforts towards vaccine development in relation to the available animal models.
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页码：381 / 390
页数：9
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