Four-year follow-up of LCAR-B38M in relapsed or refractory multiple myeloma: a phase 1, single-arm, open-label, multicenter study in China (LEGEND-2)

被引:0
作者
Wan-Hong Zhao
Bai-Yan Wang
Li-Juan Chen
Wei-Jun Fu
Jie Xu
Jie Liu
Shi-Wei Jin
Yin-Xia Chen
Xing-Mei Cao
Yun Yang
Yi-Lin Zhang
Fang-Xia Wang
Peng-Yu Zhang
Bo Lei
Liu-Fang Gu
Jian-Li Wang
Hui Zhang
Ju Bai
Yan Xu
Han Zhu
Juan Du
Hua Jiang
Xiao-Hu Fan
Jian-Yong Li
Jian Hou
Zhu Chen
Wang-Gang Zhang
Jian-Qing Mi
Sai-Juan Chen
Ai-Li He
机构
[1] The Second Affiliated Hospital of Xi’an Jiaotong University,Department of Hematology
[2] First Affiliated Hospital of Nanjing Medical University,Department of Hematology, Jiangsu Province Hospital
[3] The Second Military Medical University,Department of Hematology, Changzheng Hospital
[4] Tongji University,Department of Hematology, School of Medicine, Shanghai Fourth People’s Hospital
[5] Ruijin Hospital Affiliated With Shanghai Jiao Tong University School of Medicine,State Key Laboratory of Medical Genomics, National Research Center for Translational Medicine, Shanghai Institute of Hematology
[6] Nanjing Legend Biotech Inc.,Department of Hematology
[7] Renji Hospital Affiliated With Shanghai Jiao Tong University School of Medicine,Department of Hematology and National
[8] The Second Affiliated Hospital of Xi’an Jiaotong University,Local Joint Engineering Research Center of Biodiagnostics and Biotherapy
来源
Journal of Hematology & Oncology | / 15卷
关键词
Multiple myeloma; Chimeric antigen receptor therapy; B cell maturation antigen; Safety; Efficacy;
D O I
暂无
中图分类号
学科分类号
摘要
引用
收藏
相关论文
共 166 条
[1]  
Kumar SK(2014)Continued improvement in survival in multiple myeloma: changes in early mortality and outcomes in older patients Leukemia 28 1122-1128
[2]  
Dispenzieri A(2012)Relapsed/refractory multiple myeloma: defining refractory disease and identifying strategies to overcome resistance Semin Hematol 49 S3-15
[3]  
Lacy MQ(2017)Systematic literature review and network meta-analysis of treatment outcomes in relapsed and/or refractory multiple myeloma J Clin Oncol 35 1312-1319
[4]  
Gertz MA(2017)Novel immunotherapies for multiple myeloma Curr Hematol Malig Rep 12 344-357
[5]  
Buadi FK(2013)Chimeric antigen receptor-modified T cells for acute lymphoid leukemia N Engl J Med 368 1509-1518
[6]  
Pandey S(2018)Tisagenlecleucel in children and young adults with b-cell lymphoblastic leukemia N Engl J Med 378 439-448
[7]  
Siegel DS(2017)Chimeric antigen receptor T cells in refractory B-cell lymphomas N Engl J Med 377 2545-2554
[8]  
van Beurden-Tan CHY(2019)B cell maturation antigen-specific CAR T cells are clinically active in multiple myeloma J Clin Invest 129 2210-2221
[9]  
Franken MG(2004)BCMA is essential for the survival of long-lived bone marrow plasma cells J Exp Med 199 91-98
[10]  
Blommestein HM(2015)Targeting B-cell maturation antigen in multiple myeloma Immunotherapy 7 1187-1199