Synthesis of novel spirooxindole-pyrrolidines and evaluation of their cytotoxic activity

[1] Singh MS(2016)Progress in 1,3-dipolar cycloadditions in the recent decade: an update to strategic development towards the arsenal of organic synthesis Tetrahedron 72 1603-44

[2] Chowdhury S(2017)A diastereoselective synthesis of dispiro [oxindole-cyclohexanone] pyrrolidines by 1,3-dipolar cycloaddition Molecules 22 2134-30

[3] Koley S(1991)Horsfiline, an oxindole alkaloid from Horsfieldia superba J Org Chem 56 6527-9

[4] Anis’kov A(1992)A total synthesis of horsfiline via aryl radical cyclisation J Chem Soc Chem Commun 24 1767-32

[5] Klochkova I(1994)On the synthesis of the oxindole alkaloid: (±)-horsfiline Heterocycles 38 725-32

[6] Tumskiy R(1972)Synthesis and antiviral activities of adamantane spiro compounds. 1. Adamantane and analogous spiro-3′-pyrrolidines J Med Chem 15 129-64

[7] Yegorova A(2009)Regioselective synthesis and stereochemical structure of anti-tumor active dispiro [3H-indole-3, 2′-pyrrolidine-3′, 3″-piperidine]-2 (1H), 4″-diones Eur J Med Chem 44 1257-52

[8] Jossang A(2010)Synthesis, antibacterial activity evaluation and QSAR studies of novel dispiropyrrolidines Eur J Med Chem 45 3446-6

[9] Jossang P(2010)Regiospecific synthesis and biological evaluation of spirooxindolopyrrolizidines via [3+ 2] cycloaddition of azomethine ylide Eur J Med Chem 45 6120-19

[10] Hadi HA(2003)Synthesis, antimicrobial and antifungal activity of a new class of spiro pyrrolidines Bioorg Med Chem 11 407-98

[1] Singh MS(2016)Progress in 1,3-dipolar cycloadditions in the recent decade: an update to strategic development towards the arsenal of organic synthesis Tetrahedron 72 1603-44

[2] Chowdhury S(2017)A diastereoselective synthesis of dispiro [oxindole-cyclohexanone] pyrrolidines by 1,3-dipolar cycloaddition Molecules 22 2134-30

[3] Koley S(1991)Horsfiline, an oxindole alkaloid from Horsfieldia superba J Org Chem 56 6527-9

[4] Anis’kov A(1992)A total synthesis of horsfiline via aryl radical cyclisation J Chem Soc Chem Commun 24 1767-32

[5] Klochkova I(1994)On the synthesis of the oxindole alkaloid: (±)-horsfiline Heterocycles 38 725-32

[6] Tumskiy R(1972)Synthesis and antiviral activities of adamantane spiro compounds. 1. Adamantane and analogous spiro-3′-pyrrolidines J Med Chem 15 129-64

[7] Yegorova A(2009)Regioselective synthesis and stereochemical structure of anti-tumor active dispiro [3H-indole-3, 2′-pyrrolidine-3′, 3″-piperidine]-2 (1H), 4″-diones Eur J Med Chem 44 1257-52

[8] Jossang A(2010)Synthesis, antibacterial activity evaluation and QSAR studies of novel dispiropyrrolidines Eur J Med Chem 45 3446-6

[9] Jossang P(2010)Regiospecific synthesis and biological evaluation of spirooxindolopyrrolizidines via [3+ 2] cycloaddition of azomethine ylide Eur J Med Chem 45 6120-19

[10] Hadi HA(2003)Synthesis, antimicrobial and antifungal activity of a new class of spiro pyrrolidines Bioorg Med Chem 11 407-98