Synthesis of 3,9,9,9a-tetramethyl-1,2,3,9a-tetrahydro-9H-imidazo[1,2-a]-indol-2-ones by reaction of 2,3,3-trimethyl-3H-indole with 2-bromopropionamides

被引：0
作者：
E. Valaityte
V. Martynaitis
A. Sackus
机构：
[1] Kaunas University of Technology,Department of Organic Chemistry
来源：
Chemistry of Heterocyclic Compounds | 2004年 / 40卷 / 11期
关键词：
2-bromopropionamide; imidazo[1,2-; ]indole; spiro[2H-indole-2,3’-[3H]naphtho[2,1-; ]-pyran]; 2,3,3-trimethyl-3H-indole;
D O I：
10.1007/s10593-005-0067-x
中图分类号：
学科分类号：
摘要：
Alkylation of 2,3,3-trimethyl-3H-indole with 2-bromopropionamide and the subsequent treatment of the formed 1-(1-carbamoylethyl)-2,3,3-trimethyl-3H-indolium bromide with a base afforded 3,9,9,9a-tetramethyl-1,2,3,9a-tetrahydro-9H-imidazo[1,2-a]indol-2-one. Condensation of the 1-(1-carbamoylethyl)-2,3,3-trimethyl-3H-indolium salt with 2-hydroxy-1-naphthaldehyde gave a mixture of diastereomeric 1-(1-carbamoylethyl)spiro[2H-indole-2,3’-[3H]naphtho[2,1-b]pyrans].
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页码：1460 / 1464
页数：4
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