Design and synthesis of non-TZD peroxisome proliferator-activated receptor γ (PPARγ) modulator

被引：0
作者：
Nabajyoti Deka
Mahesh Uravane
Jessy Anthony
Sujit Kaur Bhumra
Amrutha Nair
Chandrika B-Rao
Dharmeshkumar Patel
H. Sivaramakrishnan
机构：
[1] Piramal Healthcare Limited,Department of Medicinal Chemistry
[2] Piramal Healthcare Limited,Department of Pharmacology
[3] Piramal Healthcare Limited,Department of Discovery Informatics
来源：
Medicinal Chemistry Research | 2014年 / 23卷
关键词：
Thiazolidinediones; PPARγ modulator; Antihyperglycemic agents; Adipogenesis; Glucose uptake;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Thiazolidinediones (TZDs) are an important class of compound used for the treatment of type 2 diabetes, targeting the peroxisome proliferator-activated receptor γ (PPARγ). Drug-induced hepatotoxicity, edema, and weight gain are the main concerns associated with TZDs. It was unclear whether the side effects observed are target mediated or compound mediated, but most of the TZDs activate PPARγ. This obliged developing of a new diverse class of ligands as antihyperglycemic agents including non-TZD PPAR ligands that could be highly effective, safe, and devoid of side effects. Here, we report the design and synthesis of N-(5-chloro-6-((1-phenylpiperidin-4-yl)oxy)pyridin-3-yl)benzenesulfonamide derivatives as non-TZD PPARγ modulators.
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页码：2150 / 2159
页数：9
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