Peroxiredoxin-2 and STAT3 form a redox relay for H2O2 signaling

被引：0
|
作者：
Mirko C Sobotta
Willy Liou
Sarah Stöcker
Deepti Talwar
Michael Oehler
Thomas Ruppert
Annette N D Scharf
Tobias P Dick
机构：
[1] German Cancer Research Center (DKFZ),Division of Redox Regulation
[2] DKFZ-ZMBH Alliance,undefined
[3] Core facility for Mass Spectrometry and Proteomics,undefined
[4] Zentrum für Molekulare Biologie der Universität Heidelberg (ZMBH),undefined
[5] DKFZ-ZMBH Alliance,undefined
来源：
Nature Chemical Biology | 2015年 / 11卷
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摘要：
A redox relay was identified in mammalian cells where the H2O2-reactive protein peroxiredoxin-2 oxidizes the transcription factor STAT3, resulting in the formation of transcriptionally inactive disulfide-linked oligomers.[graphic not available: see fulltext]
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页码：64 / 70
页数：6
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