Effect of a retinoid X receptor partial agonist on airway inflammation and hyperresponsiveness in a murine model of asthma

被引:0
作者
Utako Fujii
Nobuaki Miyahara
Akihiko Taniguchi
Naohiro Oda
Daisuke Morichika
Etsuko Murakami
Hikari Nakayama
Koichi Waseda
Mikio Kataoka
Hiroki Kakuta
Mitsune Tanimoto
Arihiko Kanehiro
机构
[1] Okayama University Graduate School of Medicine,Department of Hematology, Oncology, Allergy and Respiratory Medicine
[2] Dentistry,Division of Pharmaceutical Sciences
[3] and Pharmaceutical Sciences,undefined
[4] Okayama University Graduate School of Medicine,undefined
[5] Dentistry,undefined
[6] and Pharmaceutical Sciences,undefined
来源
Respiratory Research | / 18卷
关键词
Asthma; RXR; RXR partial agonist; NF-κB; Nitric oxide; Animal model;
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[11]  
Leid M(2013)Low dose bexarotene treatment rescues dopamine neurons and restores behavioral function in models of Parkinson’s disease ACS Chem Neurosci 4 1430-1438
[12]  
De Lera AR(2012)Feasibility of structural modification of retinoid X receptor agonists to separate blood glucose-lowering action from adverse effects: studies in KKA(y) type 2 diabetes model mice Biol Pharm Bull 35 629-633
[13]  
Lotan R(2001)Phase 2 and 3 clinical trial of oral bexarotene (Targretin capsules) for the treatment of refractory or persistent early-stage cutaneous T-cell lymphoma Arch Dermatol 137 581-593
[14]  
Mangelsdorf DJ(2015)RXR partial agonist produced by side chain repositioning of alkoxy RXR full agonist retains antitype 2 diabetes activity without the adverse effects J Med Chem 58 912-926
[15]  
Gronemeyer H(2015)Positron emission tomography to elucidate pharmacokinetic differences of regioisomeric retinoid x receptor agonists ACS Med Chem Lett 6 334-338
[16]  
Mangelsdorf DJ(2007)Pioglitazone is as effective as dexamethasone in a cockroach allergen-induced murine model of asthma Respir Res 8 90-3267
[17]  
Thummel C(2009)Peroxisome proliferator-activated receptor gamma agonist down-regulates IL-17 expression in a murine model of allergic airway inflammation J Immunol 183 3259-1398
[18]  
Beato M(2015)Nuclear receptor Nur77 attenuates airway inflammation in mice by suppressing NF-kappaB activity in lung epithelial cells J Immunol 195 1388-377
[19]  
Herrlich P(2006)Pirfenidone modulates airway responsiveness, inflammation, and remodeling after repeated challenge Am J Respir Cell Mol Biol 35 366-218
[20]  
Schutz G(2008)IFN-gamma production during initial infection determines the outcome of reinfection with respiratory syncytial virus Am J Respir Crit Care Med 177 208-1255