Two new polyhydroxyl polyacetylenes from fruits of Herpetospermum caudigerum

被引：0
作者：
Xin Feng
Gejia Zhong
Daji Dengba
Jun Luo
Shouying Du
机构：
[1] Beijing University of Chinese Medicine,School of Chinese Materia Medica
[2] China Tibetology Research Center,Tibetanmedicine Institute
[3] China Pharmaceutical University,Department of Natural Medicinal Chemistry
来源：
Journal of Natural Medicines | 2017年 / 71卷
关键词：
Polyacetylene; NO production; Tibetan medicine;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Two new polyhydroxy polyacetylenes, herpecaudenes A and B (1 and 2), were isolated from the ethanol extract of fruits of Herpetospermum caudigerum, an important Tibetan medicine. The structures of them were elucidated on the basis of extensive spectroscopic methods including UV, IR, HRESIMS, 1H and 13C NMR, HMBC, HSQC, and 1H-1H COSY. Compound 2 showed significant inhibitory effects on NO production in LPS-activated RAW 264.7 macrophages with IC50 values of 7.05 ± 1.59 µM.
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页码：574 / 577
页数：3
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