The role of mitochondrial dysfunction in mesenchymal stem cell senescence

被引：0
作者：
Yibo Wang
Yunlong Liu
Erman Chen
Zhijun Pan
机构：
[1] Zhejiang University School of Medicine,Department of Orthopedics, The Second Affiliated Hospital
来源：
Cell and Tissue Research | 2020年 / 382卷
关键词：
Senescence; Mesenchymal stem cells; Mitochondrial dysfunction; Reactive oxygen species; Mitophagy;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Mesenchymal stem cells (MSCs) hold enormous potential for the treatment of immune-related conditions and degenerative diseases, owing to their self-renewal and multilineage differentiation capabilities. Nevertheless, cellular senescence significantly impacts the quantity and quality of MSCs, limiting their clinical use. Mitochondria play essential roles in energy production by oxidative phosphorylation and metabolism of energy sources via the tricarboxylic acid cycle. Therefore, mitochondrial dysfunction is a primary cause of senescence in MSCs. Herein, we summarize the current knowledge regarding the mechanisms underlying mitochondrial dysfunction–associated cellular senescence. We also discuss potential methods to prevent or even reverse MSC senescence.
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页码：457 / 462
页数：5
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