Mesencephalic astrocyte-derived neurotrophic factor and its role in nervous system disease

被引：0
作者：
Zhu Li-na
Chen Deng
Xu Da
Chen Si-han
Wang Hai-jiao
Liu Ling
机构：
[1] West China Hospital,Department of Neurology
[2] Sichuan University,undefined
来源：
Neurological Sciences | 2017年 / 38卷
关键词：
NTF; MANF; Neurological disease;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Mesencephalic astrocyte-derived neurotrophic factor (MANF) is a member of the novel evolutionary conserved neurotrophic factor (NTF) family. MANF has a unique structure and an unparalleled dual mode of action that differs from other known NTFs. Recent studies have shown that MANF protects cells from endoplasmic reticulum stress. In addition, an increasing number of studies have found MANF plays an important role in nervous system disease. This review focuses on MANF, summarizing its unique structure, potential signaling pathway, and role in neurological disease.
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页码：1741 / 1746
页数：5
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