Irf7 regulates the expression of Srg3 and ferroptosis axis aggravated sepsis-induced acute lung injury

被引：0
作者：
Xinyu Ling
Shiyou Wei
Dandan Ling
Siqi Cao
Rui Chang
Qiuyun Wang
Zhize Yuan
机构：
[1] Tongji University,Department of Thoracic Surgery, Shanghai Pulmonary Hospital, School of Medicine
[2] Tongji University,Department of Anesthesiology, Shanghai Pulmonary Hospital, School of Medicine
[3] Fudan University Shanghai Cancer Center,Department of Anesthesiology
[4] Weifang Medical University,School of Clinical Medicine
[5] Tongji University,Medical Department, Shanghai Pulmonary Hospital, School of Medicine
[6] Shanghai Jiaotong University School of Medicine,Department of Anesthesiology, Ruijin Hospital
来源：
Cellular & Molecular Biology Letters | / 28卷
关键词：
Sepsis-induced acute lung injury; Irf7; Ferroptosis; NF-κB signaling pathway;
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摘要：
Srg3 is highly expressed in sepsis-induced acute lung injury.Knockdown of Srg3 suppresses lung injury symptoms in septic rats.Srg3 regulates NF-κB signaling pathway and ferroptosis.Irf7 transcriptionally regulates Srg3 and activates its transcriptional activity in sepsis-induced acute lung injury.The overexpression of Irf7 weakens the beneficial effect of Srg3 knockdown on improving sepsis-induced acute lung injury.
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