Future possibilities in the prevention of breast cancer: Role of genetic variation in breast cancer prevention

被引：0
作者：
Heather Spencer Feigelson
Brian E Henderson
机构：
[1] American Cancer Society,American Cancer Society
[2] University of Southern California,undefined
[3] National Home Office,undefined
来源：
Breast Cancer Research | / 2卷
关键词：
breast cancer; epidemiology; polymorphism; prevention; risk factors;
D O I：
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摘要：
Risk factors for breast cancer are related to endogenous hormonesand reproductive events. As such, traditional cancer prevention strategies arenot easily applicable. Tamoxifen and other selective estrogen receptormodulators (SERMs) offer a new preventive strategy for some high-risk women,but have not yet been shown to be efficacious for all women. New tools toidentify high-risk women are needed. One such tool is the development of amultigenic model of breast cancer susceptibility that can be used to screenwomen in order to identify those who carry a combination of alleles that putsthem at significantly increased risk.
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