Hairy cell leukemia

被引:0
作者
Ronan Swords
Francis Giles
机构
[1] University College Hospital Galway,Department of Haematology
[2] The University of Texas M.D. Anderson Cancer Centre,Department of Leukaemia — Unit 428
来源
Medical Oncology | 2007年 / 24卷
关键词
Hairy cell leukemia; purine analogs; pathophysiology; treatment;
D O I
暂无
中图分类号
学科分类号
摘要
Hairy cell leukemia (HCL) is a chronic B-cell lymphoproliferative disorder characterized by pancytopenia and variable infiltration of the reticuloendothelial system with “hairy” lymphocytes. HCL is more common in men than women and has a median age of diagnosis of 52 yr. Typically, patients with HCL respond well to purine analog-based therapy. The purpose of this review will be to establish the current status of HCL with respect to its pathophysiology, diagnosis, management, and future directions.
引用
收藏
页码:7 / 15
页数:8
相关论文
共 125 条
  • [1] Bouroncle BA(1958)Leukemic reticuloendotheliosis Blood 13 609-630
  • [2] Wiseman BK(1990)Epidemiology of hairy cell leukemia in Los Angeles County Cancer Res 50 3605-3609
  • [3] Doan CA(2006)Lymphoma incidence patterns by WHO subtype in the United States, 1992–2001 Blood 107 265-276
  • [4] Bernstein L(2003)Hairy cell leukemia: an update Curr Opin Hematol 10 258-266
  • [5] Newton P(1993)Hairy cell leukaemia: descriptive epidemiology and a case-control study Br J Haematol 85 714-717
  • [6] Ross RK(1985)Hairy cell leukemia: a tumor of preplasma cells Blood 65 620-629
  • [7] Morton LM(1987)Hairy cells and monocytoid B lymphocytes: are they related? Leukemia 1 298-300
  • [8] Goodman GR(1994)Gernminal centers Annu Rev Immunol 12 117-139
  • [9] Bethel KJ(2005)Absence of surface CD27 distinguishes hairy cell leukemia from other leukemic B-cell malignancies Haematologica 90 266-268
  • [10] Saven A(2004)Gene expression profiling of hairy cell leukemia reveals a phenotype related to memory B cells with altered expression of chemokine and adhesion receptors J Exp Med 199 59-68