Telomere length is a novel predictive biomarker of sensitivity to anti-EGFR therapy in metastatic colorectal cancer

[1] Arango D(2004)Molecular mechanisms of action and prediction of response to oxaliplatin in colorectal cancer cells Br J Cancer 91 1931-1946

[2] Wilson AJ(2010)Evolution in health and medicine Sackler colloquium: Genetic variation in human telomerase is associated with telomere length in Ashkenazi centenarians Proc Natl Acad Sci USA 107 1710-1717

[3] Shi Q(2009)Telomere length measurement by a novel monochrome multiplex quantitative PCR method Nucleic Acids Res 37 e21-515

[4] Corner GA(2008)KRAS wild-type state predicts survival and is associated to early radiological response in metastatic colorectal cancer treated with cetuximab Ann Oncol 19 508-1169

[5] Arañes MJ(2007)Clinical relevance of KRAS mutation detection in metastatic colorectal cancer treated by Cetuximab plus chemotherapy Br J Cancer 96 1166-1034

[6] Nicholas C(2013)Panitumumab-FOLFOX4 treatment and RAS mutations in colorectal cancer N Engl J Med 369 1023-1814

[7] Lesser M(2004)Telomere length and human telomerase reverse transcriptase expression as markers for progression and prognosis of colorectal carcinoma J Clin Oncol 22 1807-50

[8] Mariadason JM(2007)The continuum of care: a paradigm for the management of metastatic colorectal cancer Oncologist 12 38-360

[9] Augenlicht LH(2011)EGFR overexpression induces activation of telomerase via PI3K/AKT-mediated phosphorylation and transcriptional regulation through Hif1-alpha in a cellular model of oral-esophageal carcinogenesis Cancer Sci 102 351-156

[10] Atzmon G(2002)Growth-related signaling regulates activation of telomerase in regenerating hepatocytes Exp Cell Res 273 147-1961

[1] Arango D(2004)Molecular mechanisms of action and prediction of response to oxaliplatin in colorectal cancer cells Br J Cancer 91 1931-1946

[2] Wilson AJ(2010)Evolution in health and medicine Sackler colloquium: Genetic variation in human telomerase is associated with telomere length in Ashkenazi centenarians Proc Natl Acad Sci USA 107 1710-1717

[3] Shi Q(2009)Telomere length measurement by a novel monochrome multiplex quantitative PCR method Nucleic Acids Res 37 e21-515

[4] Corner GA(2008)KRAS wild-type state predicts survival and is associated to early radiological response in metastatic colorectal cancer treated with cetuximab Ann Oncol 19 508-1169

[5] Arañes MJ(2007)Clinical relevance of KRAS mutation detection in metastatic colorectal cancer treated by Cetuximab plus chemotherapy Br J Cancer 96 1166-1034

[6] Nicholas C(2013)Panitumumab-FOLFOX4 treatment and RAS mutations in colorectal cancer N Engl J Med 369 1023-1814

[7] Lesser M(2004)Telomere length and human telomerase reverse transcriptase expression as markers for progression and prognosis of colorectal carcinoma J Clin Oncol 22 1807-50

[8] Mariadason JM(2007)The continuum of care: a paradigm for the management of metastatic colorectal cancer Oncologist 12 38-360

[9] Augenlicht LH(2011)EGFR overexpression induces activation of telomerase via PI3K/AKT-mediated phosphorylation and transcriptional regulation through Hif1-alpha in a cellular model of oral-esophageal carcinogenesis Cancer Sci 102 351-156

[10] Atzmon G(2002)Growth-related signaling regulates activation of telomerase in regenerating hepatocytes Exp Cell Res 273 147-1961