Polyion complex micelles prepared by self-assembly of block-graft polycation and hyperbranched polyanion

被引：0
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作者：
Yu Dai
Hongquan Wang
Xiaojin Zhang
机构：
[1] China University of Geosciences,Faculty of Materials Science and Chemistry
来源：
Journal of Nanoparticle Research | 2017年 / 19卷
关键词：
Polyion complex micelles; Self-assembly; Block-graft polymer; Hyperbranched polymer; Drug-controlled release; Health effects;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Polyion complex (PIC) micelles were prepared by self-assembly of block-graft polycation monomethoxy poly(ethylene glycol)-block-(poly(ε-caprolactone)-graft-polyethylenimine) (PEG-b-(PCL-g-PEI)) and hyperbranched polyanion sodium carboxyl-modified hyperbranched polyesters (Hx-COONa, x = 20, 30, 40). The results from commonly used MTT assay indicated that PIC micelles had good biocompatibility. PIC micelles with N/COO− of 8/3 had appropriate size (sub-110 nm) and moderate zeta potential (~3 mV). PIC micelles were nano-sized spheres, and the average size was about 50 nm. PIC micelles had high drug loading capacity for hydrophilic drugs such as doxorubicin (DOX) hydrochloride and released the drugs under the influence of pH and ionic strength.
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