Induction and add-on therapy with Mitoxantrone and Interferon beta in multiple sclerosis

被引：0
作者：
Mauro Zaffaroni
Annalisa Rizzo
Silvana Maria Baldini
Angelo Ghezzi
Giancarlo Comi
机构：
[1] Centro Studi Sclerosi Multipla,
[2] S. Raffaele Hospital and University,undefined
来源：
Neurological Sciences | 2008年 / 29卷
关键词：
Interferon beta; Glatiramer acetate; Mitoxantrone; Combination therapy; Induction therapy; Rescue therapy;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
We retrospectively analyzed data from 70 multiple sclerosis (MS) patients treated with mitoxantrone (MX) before Interferon-β (IFN-β) because of clinically and MRI very active isolated syndrome (CIS) or relapsing-remitting MS (induction therapy) or due to breakthrough/ persistently active disease in spite of IFN-β (add-on/combination therapy), or for increased disability suggesting a secondary progression (rescue therapy). After almost 2-year follow-up, relapse rate and disability decreased very significantly in the two former groups while MX was essentially ineffective as rescue therapy. Induction therapy is a valid option for very aggressive/active CIS and MS at onset.
引用
收藏
页码：230 / 232
页数：2
相关论文
共 50 条
[41]   Interferon beta, birth weight and pregnancy in multiple sclerosis [J].
Hellwig, Kerstin ;
Agne, Heike ;
Gold, Ralf .
JOURNAL OF NEUROLOGY, 2009, 256 (05) :830-831
[42]   Antibodies against interferon-beta in multiple sclerosis [J].
Aarskog, Nina Karin ;
Maroy, Tove ;
Myhr, Kjell-Morten ;
Vedeler, Christian A. .
JOURNAL OF NEUROIMMUNOLOGY, 2009, 212 (1-2) :148-150
[43]   Experience in the treatment of multiple sclerosis with interferon beta in Galicia [J].
Romero-López, J ;
Seijo-Martínez, M ;
Del Campo, V ;
Amigo-Jorrín, MC ;
Arias, M ;
Cortés-Laíño, JA ;
Dapena-Bolaño, D ;
López-González, FJ ;
Lorenzo-González, JR ;
Marín-Sánchez, M ;
Muñoz-García, D ;
Ozaita-Arteche, G ;
Prieto, JM .
REVISTA DE NEUROLOGIA, 2003, 37 (11) :1001-1004
[44]   Multiple sclerosis, interferon beta and clinical thyroid dysfunction [J].
Kreisler, A ;
de Seze, J ;
Stojkovic, T ;
Delisse, B ;
Combelles, M ;
Vérier, A ;
Hautecoeur, P ;
Vermersch, P .
ACTA NEUROLOGICA SCANDINAVICA, 2003, 107 (02) :154-157
[45]   Oxidative modification of blood serum proteins in multiple sclerosis after interferon or mitoxantrone treatment [J].
Sadowska-Bartosz, Izabela ;
Adamczyk-Sowa, Monika ;
Gajewska, Agnieszka ;
Bartosz, Grzegorz .
JOURNAL OF NEUROIMMUNOLOGY, 2014, 266 (1-2) :67-74
[46]   Treatment de-escalation after mitoxantrone therapy: results of a phase IV, multicentre, open-label, randomized study of subcutaneous interferon beta-1a in patients with relapsing multiple sclerosis [J].
Rieckmann, Peter ;
Heidenreich, Fedor ;
Sailer, Michael ;
Zettl, Uwe K. ;
Zessack, Norbert ;
Hartung, Hans-Peter ;
Gold, Ralf .
THERAPEUTIC ADVANCES IN NEUROLOGICAL DISORDERS, 2012, 5 (01) :3-12
[47]   Absence of MxA induction is related to a poor clinical response to interferon beta treatment in multiple sclerosis patients [J].
Matas, Elisabet ;
Bau, Laura ;
Martinez-Iniesta, Maria ;
Romero-Pinel, Lucia ;
Alba Mane-Martinez, Maria ;
Martinez-Yelamos, Sergio .
JOURNAL OF NEUROLOGY, 2016, 263 (04) :722-729
[48]   Paraoxonase 1 activity in multiple sclerosis patients during mitoxantrone therapy [J].
Jamroz-Wisniewska, A. ;
Beltowski, J. ;
Stelmasiak, Z. ;
Bartosik-Psujek, H. .
ACTA NEUROLOGICA SCANDINAVICA, 2013, 127 (06) :e33-e36
[49]   Efficacy and safety of mitoxantrone, as an initial therapy, in multiple sclerosis: Experience in an Indian tertiary care setting [J].
Singhal, B. S. ;
Geeta, Sheth ;
Hundalani, Shilpa G. ;
Menon, Suresh .
NEUROLOGY INDIA, 2009, 57 (04) :418-U184
[50]   Interferon-Beta-Induced Headache in Patients with Multiple Sclerosis: Frequency and Characterization [J].
Elmazny, Alaa ;
Hamdy, Sherif M. ;
Abdel-Naseer, Maged ;
Shalaby, Nevin M. ;
Shehata, Hatem S. ;
Kishk, Nirmeen A. ;
Nada, Mona A. ;
Mourad, Husam S. ;
Hegazy, Mohamed, I ;
Abdelalim, Ahmed ;
Ahmed, Sandra M. ;
Hatem, Ghada ;
Fouad, Amr M. ;
Mahmoud, Hadel ;
Hassan, Amr .
JOURNAL OF PAIN RESEARCH, 2020, 13 :537-545
12345