Induction and add-on therapy with Mitoxantrone and Interferon beta in multiple sclerosis

被引：0
作者：
Mauro Zaffaroni
Annalisa Rizzo
Silvana Maria Baldini
Angelo Ghezzi
Giancarlo Comi
机构：
[1] Centro Studi Sclerosi Multipla,
[2] S. Raffaele Hospital and University,undefined
来源：
Neurological Sciences | 2008年 / 29卷
关键词：
Interferon beta; Glatiramer acetate; Mitoxantrone; Combination therapy; Induction therapy; Rescue therapy;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
We retrospectively analyzed data from 70 multiple sclerosis (MS) patients treated with mitoxantrone (MX) before Interferon-β (IFN-β) because of clinically and MRI very active isolated syndrome (CIS) or relapsing-remitting MS (induction therapy) or due to breakthrough/ persistently active disease in spite of IFN-β (add-on/combination therapy), or for increased disability suggesting a secondary progression (rescue therapy). After almost 2-year follow-up, relapse rate and disability decreased very significantly in the two former groups while MX was essentially ineffective as rescue therapy. Induction therapy is a valid option for very aggressive/active CIS and MS at onset.
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收藏
页码：230 / 232
页数：2
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