The Possible Role of Brain-derived Neurotrophic Factor in Epilepsy

被引：16

作者：

Alruwaili, Raed ^{[1
]}

Al-kuraishy, Hayder M. ^{[2
]}

Al-Gareeb, Ali I. ^{[2
]}

Ali, Naif H. ^{[3
]}

Alexiou, Athanasios ^{[1
,2
,3
,4
,5
]}

Papadakis, Marios ^{[6
]}

Saad, Hebatallah M. ^{[7
]}

Batiha, Gaber El-Saber ^{[8
]}

机构：

[1] Chandigarh Univ, Univ Ctr Res & Dev, Chandigarh Ludhiana Highway, Mohali, Punjab, India

[2] Funogen, Dept Res & Dev, Athens, Greece

[3] AFNP Med, Dept Res & Dev, A-1030 Vienna, Austria

[4] Novel Global Community Educ Fdn, Dept Sci & Engn, Hebersham, NSW 2770, Australia

[5] AFNP Med, A-1030 Vienna, Austria

[6] Univ Hosp Witten Herdecke, Dept Surg, Heusnerstr 40, D-42283 Wuppertal, Germany

[7] Matrouh Univ, Fac Vet Med, Dept Pathol, Matrouh 51744, Egypt

[8] Damanhour Univ, Fac Vet Med, Dept Pharmacol & Therapeut, Damanhour 22511, AlBeheira, Egypt

来源：

NEUROCHEMICAL RESEARCH | 2024年 / 49卷 / 03期

关键词：

Epilepsy; Seizure; Brain-derived neurotrophic factor; mTOR pathway; TrkB; Progranulin and alpha-synuclein; TEMPORAL-LOBE EPILEPSY; SERUM BDNF LEVELS; ALPHA-SYNUCLEIN; STATUS EPILEPTICUS; MAMMALIAN TARGET; FACTOR LEVEL; RAT MODEL; AUTOPHAGY; EXPRESSION; TRKB;

D O I：

10.1007/s11064-023-04064-x

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Epilepsy is a neurological disease characterized by repeated seizures. Despite of that the brain-derived neurotrophic factor (BDNF) is implicated in the pathogenesis of epileptogenesis and epilepsy, BDNF may have a neuroprotective effect against epilepsy. Thus, the goal of the present review was to highlight the protective and detrimental roles of BDNF in epilepsy. In this review, we also try to find the relation of BDNF with other signaling pathways and cellular processes including autophagy, mTOR pathway, progranulin (PGN), and alpha-Synuclein (alpha-Syn) which negatively and positively regulate BDNF/tyrosine kinase receptor B (TrkB) signaling pathway. Therefore, the assessment of BDNF levels in epilepsy should be related to other neuronal signaling pathways and types of epilepsy in both preclinical and clinical studies. In conclusion, there is a strong controversy concerning the potential role of BDNF in epilepsy. Therefore, preclinical, molecular, and clinical studies are warranted in this regard.

引用

页码：533 / 547

页数：15

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