Clues from Bariatric Surgery: Reversing Insulin Resistance to Heal the Heart

被引：0
作者：
Khaled Imad Khalaf
Heinrich Taegtmeyer
机构：
[1] The University of Texas Medical School at Houston,Department of Internal Medicine, Division of Cardiology
来源：
Current Diabetes Reports | 2013年 / 13卷
关键词：
Insulin resistance; Diabetes; Obesity; Bariatric surgery; Gastric bypass; Lipotoxicity;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Obesity is a state of metabolic dysregulation of the whole organism and a major contributing factor to the epidemic of insulin resistant diabetes. The nonpharmacologic treatment of obesity with bariatric surgery results in a dramatic and almost instantaneous reversal of insulin resistance. The present review collectively addresses the evidence for this phenomenon in the literature and discusses potential metabolic and neurohumoral mechanisms. We propose that nutrient restriction lowers the cell’s defense mechanisms for nutrient overload in insulin responsive organs.
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页码：245 / 251
页数：6
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