Convergence between Wnt-β-catenin and EGFR signaling in cancer

被引:0
|
作者
Tianhui Hu
Cunxi Li
机构
[1] Xiamen University Medical College,Cancer Research Center
[2] Vanderbilt University School of Medicine,Department of Medicine
来源
Molecular Cancer | / 9卷
关键词
Adenomatous Polyposis Coli; Planar Cell Polarity; Adenomatous Polyposis Coli Gene; EGFR Signaling; EGFR Activation;
D O I
暂无
中图分类号
学科分类号
摘要
Wnt and EGFR signaling play key roles in embryonic development and cell proliferation. It is well documented that dysregulation of these two pathways often leads to tumorigenesis with poor prognosis. However, the possible crosstalk between the two pathways in cancer development is largely unknown. Although some reports show that EGFR might antagonize Wnt signaling during development in Drosophila, an increasing body of evidence indicates that Wnt and EGFR signaling crosstalk and transactivate one another in development and cancer. This review summarizes recent studies on the crosstalk between Wnt and EGFR signaling in cancers and points out several possible convergence points. Wnt ligands can activate EGFR signaling through their 7-transmembrane domain receptor Frizzled while EGFR can activate β-catenin via receptor tyrosine kinase-PI3K/Akt pathway; EGFR has been shown to form a complex with β-catenin and increase the invasion and metastasis of cancer cells. NKD2, a Wnt antagonist by interacting with Dishevelled, also escorts TGFα-containing exocytic vesicles to the basolateral membrane of polarized epithelial cells. Down-regulation of NKD2 causes Wnt activation and TGFα misdelivery, suggesting its functions in cell homeostasis and prevention of tumorigenesis.
引用
收藏
相关论文
共 50 条
  • [41] Effects of Wnt-β-Catenin Signaling and Sclerostin on the Phenotypes of Rat Pheochromocytoma PC12 Cells
    Morimoto, Eisaku
    Inagaki, Kenichi
    Komatsubara, Motoshi
    Terasaka, Tomohiro
    Itoh, Yoshihiko
    Fujisawa, Satoshi
    Sasaki, Erika
    Nishiyama, Yuki
    Hara, Takayuki
    Wada, Jun
    JOURNAL OF THE ENDOCRINE SOCIETY, 2022, 6 (10)
  • [42] WNT-β Catenin Signaling as a Potential Therapeutic Target for Neurodegenerative Diseases: Current Status and Future Perspective
    Ramakrishna, Kakarla
    Nalla, Lakshmi Vineela
    Naresh, Dumala
    Venkateswarlu, Kojja
    Viswanadh, Matte Kasi
    Nalluri, Buchi N.
    Chakravarthy, Guntupalli
    Duguluri, Sajusha
    Singh, Payal
    Rai, Sachchida Nand
    Kumar, Ashish
    Singh, Veer
    Singh, Santosh Kumar
    DISEASES, 2023, 11 (03)
  • [43] SNP detection implicated in WNT-β-catenin signaling molecules as a genetic marker for involutional osteoporosis.
    Urano, T
    Fujita, M
    Hoshino, S
    Shiraki, M
    Ouchi, Y
    Inoue, S
    JOURNAL OF THE AMERICAN GERIATRICS SOCIETY, 2004, 52 (04) : S207 - S208
  • [44] Impaired Wnt-β-catenin signaling disrupts adult renal homeostasis and leads to cystic kidney ciliopathy
    Lancaster, Madeline A.
    Louie, Carrie M.
    Silhavy, Jennifer L.
    Sintasath, Louis
    DeCambre, Marvalyn
    Nigam, Sanjay K.
    Willert, Karl
    Gleeson, Joseph G.
    NATURE MEDICINE, 2009, 15 (09) : 1046 - U101
  • [45] Wnt-β-catenin signalling in liver development, health and disease
    Perugorria, Maria J.
    Olaizola, Paula
    Labiano, Ibone
    Esparza-Baquer, Aitor
    Marzioni, Marco
    Marin, Jose J. G.
    Bujanda, Luis
    Banales, Jesus M.
    NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY, 2019, 16 (02) : 121 - 136
  • [46] An update on the role of RANKL-RANK/osteoprotegerin and WNT-ß-catenin signaling pathways in pediatric diseases
    Brunetti, Giacomina
    D'Amato, Gabriele
    Chiarito, Mariangela
    Tullo, Apollonia
    Colaianni, Graziana
    Colucci, Silvia
    Grano, Maria
    Faienza, Maria Felicia
    WORLD JOURNAL OF PEDIATRICS, 2019, 15 (01) : 4 - 11
  • [47] Targeting the Wnt/β-catenin signaling pathway in cancer
    Zhang, Ya
    Wang, Xin
    JOURNAL OF HEMATOLOGY & ONCOLOGY, 2020, 13 (01)
  • [48] Targeting the Wnt/β-catenin signaling pathway in cancer
    Ya Zhang
    Xin Wang
    Journal of Hematology & Oncology, 13
  • [49] Targeting Wnt/β-Catenin Signaling for Cancer Immunotheraoy
    Wang, Bojun
    Tian, Tian
    Kalland, Karl-Henning
    Ke, Xisong
    Qu, Yi
    TRENDS IN PHARMACOLOGICAL SCIENCES, 2018, 39 (07) : 648 - 658
  • [50] Wnt-β-catenin as an epigenetic switcher in colonic Treg cells
    Cane, Stefania
    Bronte, Vincenzo
    NATURE IMMUNOLOGY, 2021, 22 (04) : 400 - 401