Amygdala Volume Differences in Autism Spectrum Disorder Are Related to Anxiety

被引：0
作者：
John D. Herrington
Brenna B. Maddox
Connor M. Kerns
Keiran Rump
Julie A. Worley
Jennifer C. Bush
Alana J. McVey
Robert T. Schultz
Judith S. Miller
机构：
[1] The Children’s Hospital of Philadelphia,Center for Autism Research
[2] University of Pennsylvania,Department of Psychiatry, Perelman School of Medicine
[3] University of Pennsylvania,Department of Pediatrics, Perelman School of Medicine
[4] Drexel University,AJ Drexel Autism Institute & Community Health & Prevention, School of Public Health
[5] Adelphi University,Center for Health Innovation
[6] SPIN Inc,Department of Psychological and Brain Sciences
[7] Indiana University,Department of Psychology
[8] Marquette University,undefined
来源：
Journal of Autism and Developmental Disorders | 2017年 / 47卷
关键词：
Amygdala; Anxiety disorders; Brain morphometry; Comorbidity;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Recent studies suggest that longstanding findings of abnormal amygdala morphology in ASD may be related to symptoms of anxiety. To test this hypothesis, fifty-three children with ASD (mean age = 11.9) underwent structural MRI and were divided into subgroups to compare those with at least one anxiety disorder diagnosis (n = 29) to those without (n = 24) and to a typically developing control group (TDC; n = 37). Groups were matched on age and intellectual level. The ASD and anxiety group showed decreased right amygdala volume (controlled for total brain volume) relative to ASD without anxiety (p = .04) and TDCs (p = .068). Results suggest that youth with ASD and co-occurring anxiety have a distinct neurodevelopmental trajectory.
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页码：3682 / 3691
页数：9
相关论文
共 361 条
[11]  
Wu B(1997)Intrinsic amygdala-cortical functional connectivity predicts social network size in humans Journal of the American Academy of Child and Adolescent Psychiatry 194 296-303
[12]  
Gee JC(2011)The Screen for Child Anxiety Related Emotional Disorders (SCARED): Scale construction and psychometric characteristics Psychiatry Research 1 27-51
[13]  
Aylward EH(1990)Structural evidence for involvement of a left amygdala-orbitofrontal network in subclinical anxiety Concepts in Neuroscience 179 303-327
[14]  
Minshew NJ(1888)The social brain: A project for integrating primate behaviour and neurophysiology in a new domain Philosophical Transactions of the Royal Society of London. B 16 1038-1051
[15]  
Goldstein G(2002)An investigation into the functions of the occipital and temporal lobes of the monkey’s brain NeuroImage 46 1324-1332
[16]  
Honeycutt NA(2007)Cerebral lobes in autism: Early hyperplasia and abnormal age effects Journal of the American Academy of Child & Adolescent Psychiatry 57 245-254
[17]  
Augustine AM(2001)Validation of the social communication questionnaire in a population cohort of children with autism spectrum disorders Neurology 48 51-57
[18]  
Yates KO(2000)Unusual brain growth patterns in early life in patients with autistic disorder: An MRI study Biological Psychiatry 60 1226-1235
[19]  
Pearlson GD(2012)A pilot study of amygdala volumes in pediatric generalized anxiety disorder NeuroImage 3 47-53
[20]  
Baas D(2013)A reliable protocol for the manual segmentation of the human amygdala and its subregions using ultra-high resolution MRI NeuroImage Clinical 214 1-8.
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