Amygdala Volume Differences in Autism Spectrum Disorder Are Related to Anxiety

被引：0
作者：
John D. Herrington
Brenna B. Maddox
Connor M. Kerns
Keiran Rump
Julie A. Worley
Jennifer C. Bush
Alana J. McVey
Robert T. Schultz
Judith S. Miller
机构：
[1] The Children’s Hospital of Philadelphia,Center for Autism Research
[2] University of Pennsylvania,Department of Psychiatry, Perelman School of Medicine
[3] University of Pennsylvania,Department of Pediatrics, Perelman School of Medicine
[4] Drexel University,AJ Drexel Autism Institute & Community Health & Prevention, School of Public Health
[5] Adelphi University,Center for Health Innovation
[6] SPIN Inc,Department of Psychological and Brain Sciences
[7] Indiana University,Department of Psychology
[8] Marquette University,undefined
来源：
Journal of Autism and Developmental Disorders | 2017年 / 47卷
关键词：
Amygdala; Anxiety disorders; Brain morphometry; Comorbidity;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Recent studies suggest that longstanding findings of abnormal amygdala morphology in ASD may be related to symptoms of anxiety. To test this hypothesis, fifty-three children with ASD (mean age = 11.9) underwent structural MRI and were divided into subgroups to compare those with at least one anxiety disorder diagnosis (n = 29) to those without (n = 24) and to a typically developing control group (TDC; n = 37). Groups were matched on age and intellectual level. The ASD and anxiety group showed decreased right amygdala volume (controlled for total brain volume) relative to ASD without anxiety (p = .04) and TDCs (p = .068). Results suggest that youth with ASD and co-occurring anxiety have a distinct neurodevelopmental trajectory.
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页码：3682 / 3691
页数：9
相关论文
共 361 条
[1]  
Aggleton JP(1981)Syndrome produced by lesions of the amygdala in monkeys ( Journal of Comparative and Physiological Psychology 95 961-977
[2]  
Passingham RE(2002)) Biological Psychiatry 51 11-17
[3]  
Amaral DG(2003)The primate amygdala and the neurobiology of social behavior: implications for understanding social anxiety Genes, Brain, and Behavior 2 295-302
[4]  
Amaral DG(2014)The amygdala and autism: implications from non-human primate studies Frontiers in Neuroinformatics 53 2145-2150
[5]  
Bauman MD(1999)The Insight ToolKit image registration framework Neurology 45 96-103
[6]  
Schumann CM(2004)MRI volumes of amygdala and hippocampus in non-mentally retarded autistic adolescents and adults Brain Research Reviews 24 711-721
[7]  
Avants BB(2004)Lateralization of amygdala activation: a systematic review of functional neuroimaging studies The Journal of Neuroscience: The Official Journal of the Society for Neuroscience 16 1388-1411
[8]  
Tustison NJ(2004)The development of mother-infant interactions after neonatal amygdala lesions in rhesus monkeys Journal of Cognitive Neuroscience 63 235-248
[9]  
Stauffer M(2014)The development of social behavior following neonatal amygdala lesions in rhesus monkeys Neuropsychologia 32 14729-14741
[10]  
Song G(2012)The amygdala as a hub in brain networks that support social life The Journal of Neuroscience 36 545-553
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