Batokine in Central Nervous System Diseases

被引:0
作者
Ming Shen
Min Zhang
Niping Mao
Zhenlang Lin
机构
[1] The Second Affiliated Hospital of Wenzhou Medical University and Yuying Children’s Hospital,Department of Neonatology
[2] Wenzhou Medical University,undefined
[3] Key Laboratory of Perinatal Medicine of Wenzhou,undefined
[4] Key Laboratory of Structural Malformations in Children of Zhejiang Province,undefined
[5] Zhejiang Provincial Clinical Research Center for Pediatric Disease,undefined
来源
Molecular Neurobiology | 2023年 / 60卷
关键词
Brown adipose tissue; FGF21; GDF15; Irisin; Central nervous system diseases;
D O I
暂无
中图分类号
学科分类号
摘要
Brown adipose tissue (BAT) is a special type of fat tissue in mammals and is also a key endocrine organ in the human body. Batokine, the endocrine effector of BAT, plays a neuroprotective role and improves the prognosis by exerting anti-apoptotic and anti-inflammatory effects, as well as by improving vascular endothelial function and other mechanisms in nerve injury diseases. The present article briefly reviewed several types of batokines related to central nervous system (CNS) diseases. Following this, the potential therapeutic value and future research direction of batokines for CNS diseases were chiefly discussed from the aspects of protective mechanism and signaling pathway.
引用
收藏
页码:7021 / 7031
页数:10
相关论文
共 334 条
[1]  
Betz MJ(2015)Human brown adipose tissue: what we have learned so far Diabetes 64 2352-2360
[2]  
Enerbäck S(2021)The heartwarming effect of brown adipose Tissue Mol Pharmacol 102 39-50
[3]  
Pinckard KM(2004)Brown adipose tissue: function and physiological significance Physiological Reviews 84 277-359
[4]  
Stanford KI(2007)Unexpected evidence for active brown adipose tissue in adult humans Am J Physiol-Endocrinol Metab 293 E444-E452
[5]  
Cannon B(2009)Cold-activated brown adipose tissue in healthy men N Engl J Med 360 1500-1508
[6]  
Nedergaard J(2009)Identification and importance of brown adipose tissue in adult humans N Engl J Med 360 1509-1517
[7]  
Nedergaard J(2013)Beyond the sympathetic tone: the new brown fat activators Cell Metabolism 17 638-643
[8]  
Bengtsson T(2019)Brown adipose crosstalk in tissue plasticity and human metabolism Endocr Rev 41 53-65
[9]  
Cannon B(2015)Of mice and men: novel insights regarding constitutive and recruitable brown adipocytes Int J Obes Supp 5 S15-S20
[10]  
van Marken Lichtenbelt WD(2020)The remaining mysteries about brown adipose tissues Cells 9 2449-1200