Human Papilloma Virus in Oral Cavity Cancer and Relation to Change in Quality of Life Following Treatment—a Pilot Study from Northern India

被引：9

作者：

Singh A.K. ^{[1
]}

Kushwaha J.K. ^{[1
]}

Anand A. ^{[1
]}

Sonkar A.A. ^{[1
]}

Husain N. ^{[2
]}

Srivastava K. ^{[3
]}

Singh S. ^{[3
]}

机构：

[1] Department of Surgery, King George’s Medical University, Lucknow, 226 003, UP

[2] Ram Manohar Lohia Institute of Medical Sciences, Lucknow, UP

[3] Department of Radiotherapy, King George’s Medical University, Lucknow, UP

来源：

Indian Journal of Surgical Oncology | 2016年 / 7卷 / 4期

关键词：

Head and neck; Human papilloma virus; Oral cavity squamous cell carcinoma; Oral neoplasms; Oropahryngeal carcinoma; Quality of life;

D O I：

10.1007/s13193-016-0559-4

中图分类号：

学科分类号：

摘要：

Human papilloma virus (HPV)-associated head and neck cancer (HNC) has generated significant amount of research interest in recent times with focus shifted to oral cavity squamous cell cancer (OCSCC) after oropharyngeal cancer. Due to high incidence of OCSCC and anecdotal reports on association of HPV infection from northern region of India, this study was conceived to investigate HPV infection and establish its association with lifestyle habits such as tobacco, alcohol consumption, oro-genital sex, number of sexual contacts, and change in quality of life posttreatment. A total of 43 primary OCSCC biopsy specimens were collected. These samples were analyzed for HPV DNA genotyping which was done by using 13 high-risk HPV real-time PCR kits. Quality of life was assessed using University of Washington questionnaire for HNC patients, which was administered pretreatment and 3-months posttreatment. HPV presence was confirmed in only three patients (7.0 %). HPV positivity did not find any statistical correlation with age, gender, residence, addiction habit, stage, tumor size, nodal status, tumor grade, and number of sexual contacts. There was no significant (p > 0.05) difference in the average percent change in QOL parameters from pretreatment to posttreatment when correlated with HPV status. © 2016, Indian Association of Surgical Oncology.

引用

页码：386 / 391

页数：5

共 70 条

[1]

Coelho K.R., Challenges of the oral cancer burden in India, J Cancer Epidemiol, 2012, (2012)

[2]

Sankaranarayanan R., Ramadas K., Thomas G., Et al., Effect of screening on oral cancer mortality in Kerala, India: a cluster-randomised controlled trial, Lancet, 365, 9475, pp. 1927-1933, (2005)

[3]

Tobacco smoke and involuntary smoking, IARC Monogr Eval Carcinog Risks Hum, 83, pp. 1-1438, (2004)

[4]

Smokeless tobacco and some tobacco-specific N-nitrosamines, IARC Monogr Eval Carcinog Risks Hum, 89, pp. 1-592, (2007)

[5]

Alcohol drinking. Epidemiological studies of cancer in humans, IARC Monogr Eval Carcinog Risks Hum, 44, pp. 153-250, (1988)

[6]

Syrjanen K., Syrjanen S., Lamberg M., Et al., Morphological and immunohistochemical evidence suggesting human papillomavirus (HPV) involvement in oral squamous cell carcinogenesis, Int J Oral Surg, 12, pp. 418-424, (1983)

[7]

Ang K.K., Harris J., Wheeler R., Et al., Human papillomavirus and survival of patients with oropharyngeal cancer, N Engl J Med, 363, pp. 24-35, (2010)

[8]

Syrjanen S., Lodi G., von Bultzingslowen I., Et al., Human papillomaviruses in oral carcinoma and oral potentially malignant disorders: a systematic review, Oral Dis, 17, pp. 58-72, (2011)

[9]

Kreimer A.R., Villa A., Nyitray A.G., Et al., The epidemiology of oral HPV infection among a multinational sample of healthy men, Cancer Epidemiol Biomark Prev, 20, pp. 172-182, (2011)

[10]

Isayeva T., Li Y., Maswahu D., Brandwein-Gensler M., Human papillomavirus in non-oropharyngeal head and neck cancers: a systematic literature review, Head Neck Pathol, 6, pp. S104-S120, (2012)

← 1 2 3 4 5 6 7 →