Dynamics of Behavioral Disorders in Transgenic Mice with Modeled Alzheimer’s Disease

被引：0

作者：

I. I. Semina

A. Z. Baichurina

E. A. Makarova

A. V. Leushina

Zh. V. Kazakevich

M. R. Gabdrakhmanova

M. A. Mukhamed’yarov

A. L. Zefirov

机构：

[1] Kazan State Medical University,

来源：

Bulletin of Experimental Biology and Medicine | 2015年 / 158卷

关键词：

Alzheimer’s disease; transgenic mice; behavioral tests; memory disturbances;

D O I：

暂无

中图分类号：

学科分类号：

摘要：

Age-related development of behavioral disorders in transgenic mice with modeled Alzheimer’s disease carrying V6S3-Tg(APP695)85Dbo Tg(PSENI)85Dbo) genotype was assessed at the age of 7.5, 10 and 20 months in the following tests: open-field, plus maze, T-maze, conditioned passive avoidance response, rotarod, conflict situation with water deprivation, behavioral despair, and arecoline tremor. The main behavioral disorder in transgenic mice at all observation terms was memory impairment in conditioning with positive (but not negative) reinforcement. At the age of 7.5 and 10 months, transgenic mice also showed signs of nonspecific excitement and anxiety, depression-like state, and symptoms of cholinergic deficit. Our results suggest that appropriate age for behavioral tests in studies of effects of potential anti-Alzheimer drugs in transgenic V6S3-Tg(APP695)85Dbo Tg(PSENI)85Dbo) mice is 7.5-10 months.

引用

页码：621 / 623

页数：2