Allergic airway inflammation induces upregulation of the expression of IL-23R by macrophages and not in CD3 + T cells and CD11c+F4/80− dendritic cells of the lung

被引：0
作者：
Maximilian Leitner
Sebastian Heck
Kenny Nguyen
Phu Quyen Nguyen
Shaza Harfoush
Eva Rosenkranz
Robert Bals
Quoc Thai Dinh
机构：
[1] Saarland University Hospital,Department of Internal Medicine V
来源：
Cell and Tissue Research | 2022年 / 389卷
关键词：
IL-23; IL-23R; Allergic airway inflammation; Macrophages; Airway neutrophilia;
D O I：
暂无
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学科分类号：
摘要：
Interleukin 23 and the interleukin 23 receptor (IL-23-IL23R) are described as the major enhancing factors for Interleukin 17 (IL-17) in allergic airway inflammation. IL-17 is considered to induce neutrophilic inflammation in the lung, which is often observed in severe, steroid-resistant asthma-phenotypes. For that reason, understanding of IL-23 and IL-17 axis is very important for future therapy strategies, targeting neutrophil pathway of bronchial asthma.
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页码：85 / 98
页数：13
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