Cost Effectiveness of High-Dose Intravenous Esomeprazole for Peptic Ulcer Bleeding

被引：0
作者：
Alan N. Barkun
Viviane Adam
Joseph J. Y. Sung
Ernst J. Kuipers
Joachim Mössner
Dennis Jensen
Robert Stuart
James Y. Lau
Emma Nauclér
Jan Kilhamn
Helena Granstedt
Bengt Liljas
Tore Lind
机构：
[1] McGill University Health Centre,Division of Gastroenterology
[2] Montreal General Hospital,Institute of Digestive Diseases
[3] Chinese University of Hong Kong,Department of Gastroenterology and Hepatology
[4] Erasmus MC University Medical Center,Medizinische Klinik und Poliklinik II
[5] University of Leipzig,David Geffen School of Medicine
[6] UCLA and CURE Digestive Diseases Research Center,undefined
[7] Glasgow Royal Infirmary,undefined
[8] AstraZeneca R&D,undefined
来源：
PharmacoEconomics | 2010年 / 28卷
关键词：
Proton Pump Inhibitor; Esomeprazole; Peptic Ulcer Bleeding; Spanish Setting; Diem Cost;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Background: Peptic ulcer bleeding (PUB) is a serious and sometimes fatal condition. The outcome of PUB strongly depends on the risk of rebleeding. A recent multinational placebo-controlled clinical trial (ClinicalTrials.gov identifier: NCT00251979) showed that high-dose intravenous (IV) esomeprazole, when administered after successful endoscopic haemostasis in patients with PUB, is effective in preventing rebleeding. From a policy perspective it is important to assess the cost efficacy of this benefit so as to enable clinicians and payers to make an informed decision regarding the management of PUB.
引用
收藏
页码：217 / 230
页数：13
相关论文
共 88 条
  • [1] Vreeburg EM(2002)Non-variceal upper gastrointestinal haemorrhage: guidelines Gut 51 1-6
  • [2] Snel P(1997)Acute upper gastrointestinal bleeding in the Amsterdam area: incidence, diagnosis, and clinical outcome Am J Gastroenterol 92 236-43
  • [3] de Bruijne JW(1997)Acute upper gastrointestinal haemorrhage in west of Scotland: case ascertainment study BMJ 315 510-4
  • [4] Blatchford O(2009)Acute upper gastrointestinal bleeding in Central Greece: the role of clinical and endoscopic variables in bleeding outcome Dig Dis Sci 54 333-41
  • [5] Davidson LA(2008)Changing trends in the epidemiology and clinical outcome of acute upper gastrointestinal bleeding in a defined geographical area in Greece J Clin Gastroenterol 42 128-33
  • [6] Murray WR(2003)Time trend analysis of incidence and outcome of acute upper GI bleeding between 1993/1994 and 2000 Am J Gastroenterol 98 1494-9
  • [7] Kapsoritakis AN(2002)Hospitalization and mortality rates from peptic ulcer disease and GI bleeding in the 1990s: relationship to sales of nonsteroidal anti-inflammatory drugs and acid suppression medications Am J Gastroenterol 97 2540-9
  • [8] Ntounas EA(2008)Estimates of costs of hospital stay for variceal and nonvariceal upper gastrointestinal bleeding in the United States Value Health 11 1-3
  • [9] Makrigiannis EA(2006)Trends in management and outcomes of acute nonvariceal upper gastrointestinal bleeding: 1993-2003 Clin GastroenterolHepatol 4 1459-66
  • [10] Theocharis GJ(1995)Steering Committee and members of the National Audit of Acute Upper Gastrointestinal Haemorrhage BMJ 311 222-6
123456789