Multifunctional porous silica nanoparticles for dual responsive drug release

被引：0
作者：
Xindang Bo
Qianqian Zhang
Xinli Li
Yanbao Zhao
机构：
[1] Henan University,Engineering Research Center for Nanomaterials
[2] Henan Vocational College of Applied Technology,Department of Chemical Engineering
来源：
Journal of Sol-Gel Science and Technology | 2020年 / 93卷
关键词：
Dual responsive; Drug delivery; Carbon dots; Fluorescent monitoring;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Porous silica nanoparticles (PSNs) were prepared by hydrolysis of tetraethyl orthosilicate and 3-aminopropyltriethoxysilane in emulsion. The PSN carriers with hierarchical pores are suitable for loading drug and controlling release. Chitosan molecules were used to close all drug-loaded pores to reduce the premature release. Hyaluronic acid (HA) modified carbon dots (CDHA) are further used to encapsulate carriers, which endow them enzyme responsiveness. The PSN carriers display pH/enzyme-responsive release and the drug release follows the first-order kinetics model. CDHA can be used not only for fluorescent marker for carriers, but also for qualitative monitoring of the drug release.
引用
收藏
页码：324 / 331
页数：7
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