Multifunctional porous silica nanoparticles for dual responsive drug release

被引：0
|
作者：
Xindang Bo
Qianqian Zhang
Xinli Li
Yanbao Zhao
机构：
[1] Henan University,Engineering Research Center for Nanomaterials
[2] Henan Vocational College of Applied Technology,Department of Chemical Engineering
来源：
Journal of Sol-Gel Science and Technology | 2020年 / 93卷
关键词：
Dual responsive; Drug delivery; Carbon dots; Fluorescent monitoring;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Porous silica nanoparticles (PSNs) were prepared by hydrolysis of tetraethyl orthosilicate and 3-aminopropyltriethoxysilane in emulsion. The PSN carriers with hierarchical pores are suitable for loading drug and controlling release. Chitosan molecules were used to close all drug-loaded pores to reduce the premature release. Hyaluronic acid (HA) modified carbon dots (CDHA) are further used to encapsulate carriers, which endow them enzyme responsiveness. The PSN carriers display pH/enzyme-responsive release and the drug release follows the first-order kinetics model. CDHA can be used not only for fluorescent marker for carriers, but also for qualitative monitoring of the drug release.
引用
收藏
页码：324 / 331
页数：7
相关论文
共 50 条
  • [1] Multifunctional porous silica nanoparticles for dual responsive drug release
    Bo, Xindang
    Zhang, Qianqian
    Li, Xinli
    Zhao, Yanbao
    JOURNAL OF SOL-GEL SCIENCE AND TECHNOLOGY, 2020, 93 (02) : 324 - 331
  • [2] Porous silica nanoparticles capped with polyethylenimine/green carbon dots for pH/redox responsive drug release
    Zhang, Qianqian
    Li, Xinli
    Peng, Lichao
    Zou, Xueyan
    Zhao, Yanbao
    INORGANIC CHEMISTRY COMMUNICATIONS, 2021, 123
  • [3] Thermo-and pH dual-responsive mesoporous silica nanoparticles for controlled drug release
    Chen, Liang
    Feng, Wei
    Zhou, Xiaojun
    Yin, Zhiqi
    He, Chuanglong
    JOURNAL OF CONTROLLED RELEASE, 2015, 213 : E69 - E70
  • [4] pH and temperature dual-responsive hollow mesoporous silica nanoparticles for drug encapsulation and delivery
    Wu, Shu
    Wang, Chen
    Chen, Xia
    Bai, Lu
    Wu, Qiuhua
    Zhang, Guolin
    JOURNAL OF DISPERSION SCIENCE AND TECHNOLOGY, 2024,
  • [5] Endogenous NO-release multi-responsive hollow mesoporous silica nanoparticles for drug encapsulation and delivery
    Wu, Shu
    Shi, Jinjing
    Chen, Xia
    Bai, Lu
    Wu, Qiuhua
    Zhang, Guolin
    COLLOIDS AND SURFACES B-BIOINTERFACES, 2023, 227
  • [6] Dual-responsive mesoporous silica nanoparticles coated with carbon dots and polymers for drug encapsulation and delivery
    Li, Xiaona
    Hu, Shun
    Lin, Zhe
    Yi, Jie
    Liu, Xue
    Tang, Xiuping
    Wu, Qiuhua
    Zhang, Guolin
    NANOMEDICINE, 2020, 15 (25) : 2447 - 2458
  • [7] Coordination Polymer Coated Mesoporous Silica Nanoparticles for pH-Responsive Drug Release
    Xing, Lei
    Zheng, Haoquan
    Cao, Yuanyuan
    Che, Shunai
    ADVANCED MATERIALS, 2012, 24 (48) : 6433 - 6437
  • [8] Multifunctional hybrid silica nanoparticles for controlled doxorubicin loading and release with thermal and pH dual response
    Hu, Xixue
    Hao, Xiaohong
    Wu, Yan
    Zhang, Jinchao
    Zhang, Xiaoning
    Wang, Paul C.
    Zou, Guozhang
    Liang, Xing-Jie
    JOURNAL OF MATERIALS CHEMISTRY B, 2013, 1 (08) : 1109 - 1118
  • [9] Multifunctional Mesoporous Silica Nanoparticles for Oral Drug Delivery
    Sreeharsha, Nagaraja
    Philip, Manish
    Krishna, Sivadas Swathi
    Viswanad, Vidya
    Sahu, Ram Kumar
    Shiroorkar, Predeepkumar Narayanappa
    Aasif, Afzal Haq
    Fattepur, Santosh
    Asdaq, Syed Mohammed Basheeruddin
    Nair, Anroop B.
    Attimarad, Mahesh
    Venugopala, Katharigatta N.
    COATINGS, 2022, 12 (03)
  • [10] A dual-responsive drug delivery system based on mesoporous silica nanoparticles covered with zipper-type peptide for intracellular transport/release
    Xu, Jun
    Li, Gaoyang
    Zhang, Yuhua
    Kang, Yuhan
    Xu, Shouhong
    Liu, Honglai
    COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS, 2021, 631 (631)
12345