Synthesis and Antibacterial Acivity of Some Novel Pyrimidine-Based Heterocycles

被引：0
作者：
W. Shehta
A. M. Abdel Hamid
机构：
[1] Zagazig University,Department of Chemistry, Faculty of Science
来源：
Russian Journal of General Chemistry | 2019年 / 89卷
关键词：
pyrimidotriazepine; pyrimidotriazine; triazolopyrimidine; cyclocondensation; heterocyclization;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Cyclization of 1,2-diamino-4(4-chlorophenyl)-6-oxo-1,6-dihydropyrimidine-5-carbonitrile 2 with a variety of electrophilic reagents results in formation of a new series of pyrimidine heterocycles including pyrimidotriazepines, pyrimidotriazines and triazolopyrimidines. Some newly synthesized compounds are tested for their antibacterial activity against Gram-positive and Gram-negative bacteria.
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页码：806 / 812
页数：6
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