KCNQ1 and type 2 diabetes: study in Hubei Han Chinese and meta-analysis in East Asian populations

被引：0
作者：
Mustafa Abdo Saif Dehwah
Shuang Zhang
Keyi Qu
Hantao Huang
Aimin Xu
Qingyang Huang
机构：
[1] Huazhong Normal University,Hubei Key Lab of Genetic Regulation and Integrative Biology, College of Life Sciences
[2] Yiling Hospital of Yichang,Li Ka Shing Faculty of Medicine
[3] The University of Hong Kong,undefined
来源：
Genes & Genomics | 2010年 / 32卷
关键词：
Association; Single nucleotide polmorphism; Type 2 diabetes;
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摘要：
Recent genome-wide association studies in East Asian poulations reported the association of KCNQ1 variants with type 2 diabetes. In the present study, we first investigated the association between rs2237892 in KCNQ1 and type 2 diabetes in a Hubei Han Chinese population (223 type 2 diabetes patients and 201 controls). The frequencies of CC genotype and C allele in type 2 diabetes patients were significantly higher than those of controls group (CC: 51.6% vs 39.3%, P=0.001; C: 72.2% vs 61.2%, P=0.001). The odds ratio for the risk allele C was 1.65 (95%CI 1.23–2.2, P=0.001). Then, we systematically reviewed the association of SNPs (rs2237892, rs2237895, rs2237897, rs2074196) in KCNQ1 with type 2 diabetes risk in a meta-analysis. Significant heterogeneity between studies was found for SNPs rs2237892 and rs2237897. Combined odds ratios of the rs2237892 C, rs2237895 C, rs2237897 C, rs2074196 G allele were 1.35 (95% CI 1.29–1.41, P<0.0001), 1.27 (95%CI 1.23–1.32, P<0.0001), 1.32 (95%CI 1.21–1.43, P<0.0001), 1.30 (95%CI 1.25–1.35, P<0.0001) respectively. Our results and meta-analysis demonstrated that KCNQ1 polymorphisms were reproducibly associated with the risk of type 2 diabetes in Han Chinese and East Asian populations.
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页码：327 / 334
页数：7
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  • [1] Casimiro M.C.(2001)Targeted disruption of the Kcnq1 gene produces a mouse model of Jervell and Lange-Nielsen Syndrome Proc. Natl. Acad. Sci. USA 98 2526-2531
  • [2] Knollmann B.C.(2010)Association study of four variants in KCNQ1 with type 2 diabetes mellitus and premature coronary artery disease in a Chinese population Mol. Bio. Rep. 37 207-712
  • [3] Ebert S.N.(2003)KCNQ1 gain-of-function mutation in familial atrial fibrillation Science 299 251-254
  • [4] Vary J.C.(1997)Properties of KvLQT1 K+ channel mutations in Romano-Ward and Jervell and Lange-Nielsen inherited cardiac arrhythmias EMBO J. 16 5472-5479
  • [5] Greene A.E.(2009)Variations in KCNQ1 are associated with type 2 diabetes and beta cell function in a Chinese population Diabetologia 52 1322-1325
  • [6] Franz M.R.(2006)Linkage and association studies of the susceptibility genes for type 2 diabetes Acta Genetica Sinica 33 573-589
  • [7] Grinberg A.(2000)Targeted disruption of the Kvlqt1 gene causes deafness and gastric hyperplasia in mice J. Clin. Invest. 106 1447-1455
  • [8] Huang S.P.(2008)Association between polymorphisms in SLC30A8, HHEX, CDKN2A/B, IGF2BP2, FTO, WFS1, CDKAL1, KCNQ1 and type 2 diabetes in the Korean population J. Hum. Genet. 53 991-998
  • [9] Pfeifer K.(2010)Common variants in FLNB/CRTAP, not ARHGEF3 at 3p, are associated with osteoporosis in southern Chinese women Osteoporos. Int. 21 1009-1020
  • [10] Chen Z.(2009)Variants in KCNQ1 are associated with susceptibility to type 2 diabetes in the population of mainland China Diabetologia 52 1315-1321
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