Structural basis for high-affinity fluorophore binding and activation by RNA Mango

被引：0

作者：

Robert J Trachman

Natalia A Demeshkina

Matthew W L Lau

Shanker Shyam S Panchapakesan

Sunny C Y Jeng

Peter J Unrau

Adrian R Ferré-D'Amaré

机构：

[1] Biochemistry and Biophysics Center,Department of Molecular Biology and Biochemistry

[2] National Heart,undefined

[3] Lung and Blood Institute,undefined

[4] Simon Fraser University,undefined

[5] Burnaby,undefined

来源：

Nature Chemical Biology | 2017年 / 13卷

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摘要：

A crystal structure of the RNA aptamer Mango bound to a thiazole orange–derived fluorophore reveals a three-tiered G-quadruplex structure, which, together with three flap-like nucleotides, constrains the fluorophore into its active conformation.[graphic not available: see fulltext]

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页码：807 / 813

页数：6

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