Structural basis for high-affinity fluorophore binding and activation by RNA Mango

被引：0
作者：
Robert J Trachman
Natalia A Demeshkina
Matthew W L Lau
Shanker Shyam S Panchapakesan
Sunny C Y Jeng
Peter J Unrau
Adrian R Ferré-D'Amaré
机构：
[1] Biochemistry and Biophysics Center,Department of Molecular Biology and Biochemistry
[2] National Heart,undefined
[3] Lung and Blood Institute,undefined
[4] Simon Fraser University,undefined
[5] Burnaby,undefined
来源：
Nature Chemical Biology | 2017年 / 13卷
关键词：
D O I：
暂无
中图分类号：
学科分类号：
摘要：
A crystal structure of the RNA aptamer Mango bound to a thiazole orange–derived fluorophore reveals a three-tiered G-quadruplex structure, which, together with three flap-like nucleotides, constrains the fluorophore into its active conformation.[graphic not available: see fulltext]
引用
收藏
页码：807 / 813
页数：6
相关论文
共 50 条
  • [21] Structural basis for binding of human IgG1 to its high-affinity human receptor FcγRI
    Masato Kiyoshi
    Jose M.M. Caaveiro
    Takeaki Kawai
    Shinya Tashiro
    Teruhiko Ide
    Yoshiharu Asaoka
    Kouta Hatayama
    Kouhei Tsumoto
    Nature Communications, 6
  • [22] Structural basis for the inhibition of HIV-1 Nef by a high-affinity binding single-domain antibody
    Luelf, Sebastian
    Matz, Julie
    Rouyez, Marie-Christine
    Jaerviluoma, Annika
    Saksela, Kalle
    Benichou, Serge
    Geyer, Matthias
    RETROVIROLOGY, 2014, 11
  • [23] Structural basis for the inhibition of HIV-1 Nef by a high-affinity binding single-domain antibody
    Sebastian Lülf
    Julie Matz
    Marie-Christine Rouyez
    Annika Järviluoma
    Kalle Saksela
    Serge Benichou
    Matthias Geyer
    Retrovirology, 11
  • [24] Structural basis for binding of human IgG1 to its high-affinity human receptor FcγRI
    Kiyoshi, Masato
    Caaveiro, Jose M. M.
    Kawai, Takeaki
    Tashiro, Shinya
    Ide, Teruhiko
    Asaoka, Yoshiharu
    Hatayama, Kouta
    Tsumoto, Kouhei
    NATURE COMMUNICATIONS, 2015, 6
  • [25] The structural and energetic basis for high selectivity in a high-affinity protein-protein interaction
    Meenan, Nicola A. G.
    Sharma, Amit
    Fleishman, Sarel J.
    MacDonald, Colin J.
    Morel, Bertrand
    Boetzel, Ruth
    Moore, Geoffrey R.
    Baker, David
    Kleanthous, Colin
    PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2010, 107 (22) : 10080 - 10085
  • [26] Molecular basis of the high-affinity activation of type 1 ryanodine receptors by imperatoxin A
    Lee, CW
    Lee, EH
    Takeuchi, K
    Takahashi, H
    Shimada, I
    Sato, K
    Shin, SY
    Kim, DH
    Kim, JI
    BIOCHEMICAL JOURNAL, 2004, 377 : 385 - 394
  • [27] Structural determinants for high-affinity zolpidem binding to GABA-A receptors
    Sancar, Feyza
    Ericksen, Spencer S.
    Kucken, Amy M.
    Teissere, Jeremy A.
    Czajkowski, Cynthia
    MOLECULAR PHARMACOLOGY, 2007, 71 (01) : 38 - 46
  • [28] INTERACTIONS OF STEROLS WITH ANTIESTROGEN-BINDING SITES - STRUCTURAL REQUIREMENTS FOR HIGH-AFFINITY BINDING
    HWANG, PLH
    MATIN, A
    JOURNAL OF LIPID RESEARCH, 1989, 30 (02) : 239 - 245
  • [29] Structural basis for high-affinity peptide inhibition of human Pin1
    Zhang, Yan
    Daum, Sebastian
    Wildemann, Dirk
    Zhou, Xiao Zhen
    Verdecia, Mark A.
    Bowman, Marianne E.
    Luecke, Christian
    Hunter, Tony
    Lu, Kun-Ping
    Fischer, Gunter
    Noel, Joseph P.
    ACS CHEMICAL BIOLOGY, 2007, 2 (05) : 320 - 328
  • [30] Structural Insights into the Mechanism of High-Affinity Binding of Ochratoxin A by a DNA Aptamer
    Xu, Guohua
    Zhao, Jiajing
    Yu, Hao
    Wang, Chen
    Huang, Yangyu
    Zhao, Qiang
    Zhou, Xin
    Li, Conggang
    Liu, Maili
    JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2022, 144 (17) : 7731 - 7740
12345