Structural basis for high-affinity fluorophore binding and activation by RNA Mango

被引：0
|
作者：
Robert J Trachman
Natalia A Demeshkina
Matthew W L Lau
Shanker Shyam S Panchapakesan
Sunny C Y Jeng
Peter J Unrau
Adrian R Ferré-D'Amaré
机构：
[1] Biochemistry and Biophysics Center,Department of Molecular Biology and Biochemistry
[2] National Heart,undefined
[3] Lung and Blood Institute,undefined
[4] Simon Fraser University,undefined
[5] Burnaby,undefined
来源：
Nature Chemical Biology | 2017年 / 13卷
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摘要：
A crystal structure of the RNA aptamer Mango bound to a thiazole orange–derived fluorophore reveals a three-tiered G-quadruplex structure, which, together with three flap-like nucleotides, constrains the fluorophore into its active conformation.[graphic not available: see fulltext]
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页码：807 / 813
页数：6
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